About: Angiopoietin-2 as a marker of endothelial activation is a good predictor factor for intensive care unit admission of COVID-19 patients

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About: Angiopoietin-2 as a marker of endothelial activation is a good predictor factor for intensive care unit admission of COVID-19 patients Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Angiopoietin-2 as a marker of endothelial activation is a good predictor factor for intensive care unit admission of COVID-19 patients
Creator	Diehl, Jean-Luc Boussier, Jeremy Charbit, Bruno Debuc, Benjamin Duffy, Darragh Goudot, Guillaume Hadjadj, Jérôme Hauw-Berlemont, Caroline Mirault, Tristan Smadja, David Terrier, Benjamin Augy, Jean-Loup Chocron, · Gaussem, · Gendron, Nicolas Guerin, Coralie Juvin, Philippe Khider, Lina Messas, · Peron, Nicolas Planquette, · Sanchez, · Yatim, ·
Source	Medline; PMC
abstract	BACKGROUND: Coronavirus disease-2019 (COVID-19), a respiratory disease has been associated with ischemic complications, coagulation disorders, and an endotheliitis. OBJECTIVES: To explore endothelial damage and activation-related biomarkers in COVID-19 patients with criteria of hospitalization for referral to intensive care unit (ICU) and/or respiratory worsening. METHODS: Analysis of endothelial and angiogenic soluble markers in plasma from patients at admission. RESULTS: Study enrolled 40 consecutive COVID-19 patients admitted to emergency department that fulfilled criteria for hospitalization. Half of them were admitted in conventional wards without any ICU transfer during hospitalization; whereas the 20 others were directly transferred to ICU. Patients transferred in ICU were more likely to have lymphopenia, decreased SpO2 and increased D-dimer, CRP and creatinine levels. In those patients, soluble E-selectin and angiopoietin-2 were significantly increased (p value at 0.009 and 0.003, respectively). Increase in SELE gene expression (gene coding for E-selectin protein) was confirmed in an independent cohort of 32 patients using a whole blood gene expression profile analysis. In plasma, we found a strong association between angiopoetin-2 and CRP, creatinine and D-dimers (with p value at 0.001, 0.001 and 0.003, respectively). ROC curve analysis identified an Angiopoietin-2 cut-off of 5000 pg/mL as the best predictor for ICU outcome (Se = 80.1%, Sp = 70%, PPV = 72.7%, NPV = 77%), further confirmed in multivariate analysis after adjustment for creatinine, CRP or D-dimers. CONCLUSION: Angiopoietin-2 is a relevant predictive factor for ICU direct admission in COVID-19 patients. This result showing an endothelial activation reinforces the hypothesis of a COVID-19-associated microvascular dysfunction.
has issue date	2020-05-27(xsd:dateTime)
bibo:doi	10.1007/s10456-020-09730-0
bibo:pmid	32458111
has license	no-cc
sha1sum (hex)	ab5e3a99004517d2fd913dc394b91897b71f0b61
schema:url	https://doi.org/10.1007/s10456-020-09730-0
resource representing a document's title	Angiopoietin-2 as a marker of endothelial activation is a good predictor factor for intensive care unit admission of COVID-19 patients
has PubMed Central identifier	PMC7250589
has PubMed identifier	32458111
schema:publication	Angiogenesis
resource representing a document's body	covid:ab5e3a99004517d2fd913dc394b91897b71f0b61#body_text
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