About: Acute systemic DNA damage in youth does not impair immune defense with aging

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Acute systemic DNA damage in youth does not impair immune defense with aging Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Acute systemic DNA damage in youth does not impair immune defense with aging
Creator	Hayashi, Tomonori Nakachi, Kei Petravic, Janka Nikolich-Zugich, Janko Pugh, Jason Smithey, Megan Foster, Sarah Padilla-Torres, Jose Sukhina, Alona Uhrlaub, Jennifer
Source	Medline; PMC
abstract	Aging‐related decline in immunity is believed to be the main driver behind decreased vaccine efficacy and reduced resistance to infections in older adults. Unrepaired DNA damage is known to precipitate cellular senescence, which was hypothesized to be the underlying cause of certain age‐related phenotypes. Consistent with this, some hallmarks of immune aging were more prevalent in individuals exposed to whole‐body irradiation (WBI), which leaves no anatomical repository of undamaged hematopoietic cells. To decisively test whether and to what extent WBI in youth will leave a mark on the immune system as it ages, we exposed young male C57BL/6 mice to sublethal WBI (0.5–4 Gy), mimicking human survivor exposure during nuclear catastrophe. We followed lymphocyte homeostasis thorough the lifespan, response to vaccination, and ability to resist lethal viral challenge in the old age. None of the irradiated groups showed significant differences compared with mock‐irradiated (0 Gy) animals for the parameters measured. Even the mice that received the highest dose of sublethal WBI in youth (4 Gy) exhibited equilibrated lymphocyte homeostasis, robust T‐ and B‐cell responses to live attenuated West Nile virus (WNV) vaccine and full survival following vaccination upon lethal WNV challenge. Therefore, a single dose of nonlethal WBI in youth, resulting in widespread DNA damage and repopulation stress in hematopoietic cells, leaves no significant trace of increased immune aging in a lethal vaccine challenge model.
has issue date	2016-04-13(xsd:dateTime)
bibo:doi	10.1111/acel.12478
bibo:pmid	27072188
has license	cc-by
sha1sum (hex)	ab70ed497469460f2ec13fcfe51611005fab867a
schema:url	https://doi.org/10.1111/acel.12478
resource representing a document's title	Acute systemic DNA damage in youth does not impair immune defense with aging
has PubMed Central identifier	PMC4933672
has PubMed identifier	27072188
schema:publication	Aging Cell
resource representing a document's body	covid:ab70ed497469460f2ec13fcfe51611005fab867a#body_text
is schema:about of	named entity 'DNA DAMAGE' named entity 'homeostasis' named entity 'vaccine' named entity 'efficacy' named entity 'model' named entity 'exposed' named entity 'YOUNG' named entity 'IMPAIR' named entity 'AGING' named entity 'CELLS' named entity 'IMMUNE' named entity 'INDIVIDUALS' named entity 'EXPOSED' named entity 'LYMPHOCYTE HOMEOSTASIS' named entity 'REPOSITORY' named entity 'MAIN' named entity 'VACCINATION' named entity 'EXTENT' named entity 'WHAT' named entity 'RECEIVED' named entity 'AGES' named entity 'SURVIVOR' named entity 'SIGNIFICANT' named entity 'YOUTH' named entity 'YOUTH' named entity 'AGE' named entity 'MICE' named entity 'RESISTANCE TO' named entity 'MARK' named entity 'CHALLENGE' named entity 'DEFENSE' named entity 'ACUTE' named entity 'DOES NOT' named entity 'IMMUNE' named entity 'NUCLEAR' named entity 'RESPONSE TO' named entity 'MALE' named entity 'DRIVER' named entity 'CELLULAR SENESCENCE' named entity 'HUMAN' named entity 'EXPOSED TO' named entity 'CONSISTENT WITH' named entity 'INCREASED' named entity 'DOSE' named entity 'IRRADIATED' named entity 'PARAMETERS' named entity 'ANATOMICAL' named entity 'RESULTING IN' named entity 'INFECTIONS' named entity 'IMMUNITY' named entity 'FOLLOWING' named entity 'SINGLE' named entity 'UNDERLYING' named entity 'LIFESPAN' named entity 'GROUPS' named entity 'MEASURED' named entity 'LEAVE' named entity 'RESPONSES' named entity 'STRESS' named entity 'FOLLOWED' named entity 'VIRAL' named entity 'UNDAMAGED' named entity 'PRECIPITATE' named entity 'VACCINE' named entity 'KNOWN' named entity 'AGING' named entity 'WNV' named entity 'CAUSE' named entity 'DECREASED' named entity 'DECLINE' named entity 'B-CELL' named entity 'RELATED'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software