About: The G-Quadruplex/Helicase World as a Potential Antiviral Approach Against COVID-19

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The G-Quadruplex/Helicase World as a Potential Antiviral Approach Against COVID-19
Creator	Tozzi, Alberto Alisi, Anna Panera, Nadia
Source	Medline; PMC
abstract	G-Quadruplexes (G4s) are non-canonical secondary structures formed within guanine-rich regions of DNA or RNA. G4 sequences/structures have been detected in human and in viral genomes, including Coronaviruses Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and SARS-CoV-2. Here, we outline the existing evidence indicating that G4 ligands and inhibitors of SARS-CoV-2 helicase may exert some antiviral activity reducing viral replication and can represent a potential therapeutic approach to tackle the COVID-19 pandemic due to SARS-CoV-2 infection. We also discuss how repositioning of FDA-approved drugs against helicase activity of other viruses, could represent a rapid strategy to limit deaths associated with COVID-19 pandemic.
has issue date	2020-05-25(xsd:dateTime)
bibo:doi	10.1007/s40265-020-01321-z
bibo:pmid	32451923
has license	no-cc
sha1sum (hex)	abc1ebf57f58456232bb708b9a9062890fa85e42
schema:url	https://doi.org/10.1007/s40265-020-01321-z
resource representing a document's title	The G-Quadruplex/Helicase World as a Potential Antiviral Approach Against COVID-19
has PubMed Central identifier	PMC7246970
has PubMed identifier	32451923
schema:publication	Drugs
resource representing a document's body	covid:abc1ebf57f58456232bb708b9a9062890fa85e42#body_text
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