About: Angiotensin-converting enzyme polymorphism affects outcome of local Chinese with acute lung injury

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Angiotensin-converting enzyme polymorphism affects outcome of local Chinese with acute lung injury Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Angiotensin-converting enzyme polymorphism affects outcome of local Chinese with acute lung injury
Creator	Yang, Yi Chen, Guang-Jian Lu, Xiao-Min Qiu, Hai-Bo
Source	Elsevier; Medline; PMC
abstract	Summary Introduction Acute Lung Injury (ALI) with genetic predisposition is fatal. Relationship between angiotensin-converting enzyme insertion/deletion (ACE I/D) polymorphism and the prognosis of local Chinese patients with ALI was investigated; meanwhile, the mechanisms involved were explored. Methods 101 ALI patients, 408 non-ALI patients and 236 healthy blood donors were enrolled. ACE I/D polymorphism was detected by polymerase chain reaction, then ACE genotype (II, ID, DD) and allele (I, D) frequencies were compared. Clinical data of ALI patients was calculated. Also, peripheral blood mononuclear cells (PBMC) were isolated from healthy volunteers with different ACE genotypes. Lipopolysaccharide (LPS)-induced ACE gene mRNA expression and ACE activity was measured. Results There was no significant difference in the frequencies of the genotypes and alleles. Acute Physiology and Chronic Health Evaluation (APACHE) II score was higher in DD subgroup than in II subgroup (19.7 ± 8.7 and 15.6 ± 6.2; P < 0.05). The 28-day mortality was significantly different (17.4%, 26.8%, and 64.3% for II, ID, and DD; P = 0.013). DD genotype was the independent prognostic factor for 28-day outcome. Furthermore, LPS-induced ACE mRNA expression and ACE activity from PBMC in DD genotype subgroup were both significantly higher than those in the other two subgroups. Conclusions ACE I/D polymorphism is a prognostic factor for ALI. Patients with the DD genotype have higher mortality of ALI. Polymorphism influences the expression of ACE gene in LPS-stimulated PBMC, DD genotype leads to higher level of mRNA and enzyme activity. It may be one of the mechanisms involved.
has issue date	2011-10-31(xsd:dateTime)
bibo:doi	10.1016/j.rmed.2011.06.009
bibo:pmid	21742477
has license	els-covid
sha1sum (hex)	abf6140f5332cfd3d4c2c546658e9c85515bf446
schema:url	https://doi.org/10.1016/j.rmed.2011.06.009
resource representing a document's title	Angiotensin-converting enzyme polymorphism affects outcome of local Chinese with acute lung injury
has PubMed Central identifier	PMC7126786
has PubMed identifier	21742477
schema:publication	Respiratory Medicine
resource representing a document's body	covid:abf6140f5332cfd3d4c2c546658e9c85515bf446#body_text
is schema:about of	named entity 'CHINESE' named entity 'patients' named entity 'mRNA' named entity 'genotypes' named entity 'expression' named entity 'PBMC' named entity 'independent' named entity 'expression' named entity 'ACE' named entity 'involved' named entity 'activity' named entity 'peripheral blood mononuclear cells' named entity 'ALI' named entity 'acute lung injury' named entity 'D I' named entity 'INVOLVED' named entity 'COMPARED' named entity '6111' named entity 'PROGNOSTIC FACTOR' named entity 'METHODS' named entity 'SCORE' named entity 'DD GENOTYPE' named entity 'INDEPENDENT' named entity 'GENETIC PREDISPOSITION' named entity 'DIFFERENT' named entity '105' named entity 'OUTCOME' named entity 'MAY BE' named entity 'PERIPHERAL BLOOD MONONUCLEAR CELLS' named entity 'LEVEL' named entity 'POLYMERASE CHAIN REACTION' named entity 'DAY' named entity 'ISOLATED' named entity 'LPS' named entity 'H O' named entity 'R M' named entity 'DIFFERENCE' named entity 'LOCAL' covid:arg/abf6140f5332cfd3d4c2c546658e9c85515bf446 named entity 'C O' named entity 'N A' named entity 'ACUTE LUNG INJURY' named entity 'NON-' named entity 'ACUTE LUNG INJURY' named entity 'ANGIOTENSIN-CONVERTING ENZYME' named entity '6.2' named entity '408' named entity 'POLYMORPHISM' named entity 'OUTCOME' named entity 'LOCAL' named entity 'HEALTHY VOLUNTEERS' named entity 'MEASURED' named entity 'MATTER' named entity 'SIGNIFICANT' named entity 'MECHANISMS' named entity 'PROGNOSIS' named entity 'ANGIOTENSIN-CONVERTING ENZYME' named entity 'ONE OF' named entity 'LIPOPOLYSACCHARIDE' named entity 'STIMULATED' named entity 'V A' named entity 'ENROLLED' named entity 'RESULTS' named entity 'L H' named entity 'POLYMORPHISM' named entity 'I E' named entity 'GENOTYPE' named entity 'ENZYME ACTIVITY' named entity 'FOR II' named entity 'ACE' named entity 'L S' named entity 'MRNA EXPRESSION' named entity 'HEALTHY' named entity 'SUBGROUP' named entity 'HAVE' named entity 'MORTALITY' named entity 'CALCULATED' named entity 'HIGHER'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software