About: STAT2 Limits Host Species Specificity of Human Metapneumovirus

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	STAT2 Limits Host Species Specificity of Human Metapneumovirus
Creator	García-Sastre, Adolfo Zhang, Yu Williams, John Rogers, Meredith Miranda-Katz, Margot Oury, Tim Uccellini, Melissa
source	PMC
abstract	The host tropism of viral infection is determined by a variety of factors, from cell surface receptors to innate immune signaling. Many viruses encode proteins that interfere with host innate immune recognition in order to promote infection. STAT2 is divergent between species and therefore has a role in species restriction of some viruses. To understand the role of STAT2 in human metapneumovirus (HMPV) infection of human and murine tissues, we first infected STAT2(−/−) mice and found that HMPV could be serially passaged in STAT2(−/−), but not WT, mice. We then used in vitro methods to show that HMPV inhibits expression of both STAT1 and STAT2 in human and primate cells, but not in mouse cells. Transfection of the murine form of STAT2 into STAT2-deficient human cells conferred resistance to STAT2 inhibition. Finally, we sought to understand the in vivo role of STAT2 by infecting hSTAT2 knock-in mice with HMPV, and found that mice had increased weight loss, inhibition of type I interferon signaling, and a Th2-polarized cytokine profile compared to WT mice. These results indicate that STAT2 is a target of HMPV in human infection, while the murine version of STAT2 restricts tropism of HMPV for murine cells and tissue.
has issue date	2020-07-04(xsd:dateTime)
bibo:doi	10.3390/v12070724
bibo:pmid	32635475
has license	cc-by
sha1sum (hex)	ac0a56f24cb11f56a71dfdaa1008c5d971d101b5
schema:url	https://doi.org/10.3390/v12070724
resource representing a document's title	STAT2 Limits Host Species Specificity of Human Metapneumovirus
has PubMed Central identifier	PMC7412095
has PubMed identifier	32635475
schema:publication	Viruses
resource representing a document's body	covid:ac0a56f24cb11f56a71dfdaa1008c5d971d101b5#body_text
is schema:about of	named entity 'inhibition' named entity 'STAT2' named entity 'mice' named entity 'STAT2' named entity 'STAT2' named entity 'human' named entity 'STAT2' named entity 'RECOGNITION' named entity 'FORM' named entity 'RESULTS' named entity 'INFECTED' named entity 'CYTOKINE PROFILE' named entity 'MICE' named entity 'PROTEINS' named entity 'MURINE' covid:arg/ac0a56f24cb11f56a71dfdaa1008c5d971d101b5 named entity 'STAT2' named entity 'Transfection' named entity 'mice' named entity 'factors' named entity 'STAT2' named entity 'cells' named entity 'proteins' named entity 'immune recognition' named entity 'mice' named entity 'murine' named entity 'viruses' named entity 'host tropism' named entity 'innate immune signaling' named entity 'STAT2' named entity 'infection' named entity 'mice' named entity 'Transfection' named entity 'STAT1' named entity 'mice' named entity 'STAT2' named entity 'type I interferon' named entity 'STAT2' named entity 'STAT2' named entity 'STAT2' named entity 'viral infection' named entity 'Human Metapneumovirus' named entity 'STAT2' named entity 'PEER REVIEW' named entity 'viral titers' named entity 'innate immune response' named entity 'STAT2' named entity 'inflammation' named entity 'allergy' named entity 'passaging' named entity 'ISGs' named entity 'homogenate' named entity 'IL-5' named entity 'infection' named entity 'mice' named entity 'HMPV' named entity 'Life Technologies' named entity 'weight loss' named entity 'innate immune response' named entity 'GFP' named entity 'homogenate' named entity 'IL-4' named entity 'adaptive immunity' named entity 'murine' named entity 'Tris-buffered saline' named entity 'HMPV' named entity 'STAT1' named entity 'U3A' named entity 'murine' named entity 'New York' named entity 'fluorescent' named entity 'paramyxovirus' named entity 'STAT1' named entity 'mice' named entity 'HMPV'

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