About: Serial change of neutrophil extracellular traps in tracheal aspirate of patients with acute respiratory distress syndrome: report of three cases

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About: Serial change of neutrophil extracellular traps in tracheal aspirate of patients with acute respiratory distress syndrome: report of three cases Goto Sponge NotDistinct Permalink

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Serial change of neutrophil extracellular traps in tracheal aspirate of patients with acute respiratory distress syndrome: report of three cases
Creator	Hamaguchi, Shigeto Hirose, Tomoya Kojima, Takashi Ogura, Hiroshi Ojima, Masahiro Shimazu, Takeshi Tasaki, Osamu Tomono, Kazunori Yamamoto, Norihisa
topic	covid:ac1632dd166e137cd82880670bc4107834f2467b#this
Source	PMC
abstract	BACKGROUND: Neutrophil extracellular traps (NETs) are fibrous structures released from activated neutrophils. NET formation has been reported to be associated with acute respiratory distress syndrome (ARDS). However, there are no reports dealing with serial changes of NET formation in tracheal aspirate of ARDS patients. CASE PRESENTATION: We report three cases of ARDS. Case 1 is a 69-year-old man with necrotizing fasciitis of the buttocks, case 2 is a 49-year-old woman with extensive burns (80% of total body surface), and case 3 is a 73-year-old woman with severe bacterial pneumonia. We found abundant expression of citrullinated histone H3 (Cit-H3) and the formation of NETs at the onset of ARDS in all cases. The amounts of Cit-H3 and NETs decreased with the amelioration of respiratory failure in cases 1 and 2. In case 2, the amounts of Cit-H3 and NETs increased with aggravation of infection and respiratory status. In case 3, the abundant expression of Cit-H3 and NETs persisted; the patient did not recover from ARDS and eventually died. Cit-H3 and NETs were found in tracheal aspirates even if the patients had no direct injury to the lung as in cases 1 and 2. CONCLUSIONS: In these three cases, the formation of NETs was observed in tracheal aspirate of patients with ARDS by either direct or indirect insults to the lung. The amount of NET formation changed dynamically over the clinical course of each patient.
has issue date	2020-04-10(xsd:dateTime)
bibo:doi	10.1186/s40560-020-00444-5
bibo:pmid	32308985
has license	cc-by
sha1sum (hex)	ac1632dd166e137cd82880670bc4107834f2467b
schema:url	https://doi.org/10.1186/s40560-020-00444-5
resource representing a document's title	Serial change of neutrophil extracellular traps in tracheal aspirate of patients with acute respiratory distress syndrome: report of three cases
has PubMed Central identifier	PMC7149861
has PubMed identifier	32308985
schema:publication	J Intensive Care
resource representing a document's body	covid:ac1632dd166e137cd82880670bc4107834f2467b#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/ac1632dd166e137cd82880670bc4107834f2467b
is schema:about of	named entity 'NETs' named entity 'body' named entity 'activated' named entity 'Case' named entity 'structures' named entity 'NET' named entity 'tracheal' named entity 'insults' named entity 'case' named entity 'respiratory failure' named entity 'ARDS' named entity 'died' named entity 'case' named entity 'NETs' named entity 'cases' named entity 'recover' named entity 'lung' named entity 'NET' named entity 'aspirate' named entity 'necrotizing fasciitis' named entity 'patients' named entity 'onset' named entity 'formation' named entity 'acute respiratory distress syndrome' named entity 'NETs' named entity 'ARDS' named entity 'lung' named entity 'NETs' named entity 'histone H3' named entity 'Neutrophil extracellular traps' named entity 'NETs' named entity 'phagocytosis' named entity 'Neutrophil extracellular traps' named entity 'bacteria' named entity 'cytokines' named entity 'compartment syndrome' named entity 'Gram staining' named entity 'aspirates' named entity 'blood vessels' named entity 'necrotizing fasciitis' named entity 'tracheal' named entity 'alveolar' named entity 'bloodstream' named entity 'NETs' named entity 'wound infection' named entity 'intubated' named entity 'ARDS' named entity 'histones' named entity 'feeding tube' named entity 'pneumonia' named entity 'NETs' named entity 'Pseudomonas aeruginosa' named entity 'acute inflammatory' named entity 'NETs' named entity 'NETs' named entity 'respiratory failure' named entity 'Deoxyribonucleic acid' named entity 'histone H3' named entity 'NETs' named entity 'tracheal' named entity 'lung' named entity 'aspirates' named entity 'debridement' named entity 'bacterial pneumonia' named entity 'aspirates' named entity 'ARDS' named entity 'high fever' named entity 'tracheal' named entity 'citrullinated' named entity 'NETs' named entity 'critical illness'

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