About: PCAF interacts with XBP-1S and mediates XBP-1S-dependent transcription

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About: PCAF interacts with XBP-1S and mediates XBP-1S-dependent transcription Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	PCAF interacts with XBP-1S and mediates XBP-1S-dependent transcription
Creator	Chao, Chu, Jialing Koh, Vikneswari Lee, Ling Lew, Kai Qiao, Jing Rajasegaran, Jin Teo, Sheng-Hao
Source	Medline; PMC
abstract	X-box binding protein 1 (XBP-1) is a key regulator required for cellular unfolded protein response (UPR) and plasma cell differentiation. In addition, involvement of XBP-1 in host cell–virus interaction and transcriptional regulation of viruses, such as human T-lymphotropic virus type 1 (HTLV-1), has been revealed recently. Two XBP-1 isoforms, XBP-1U and XBP-1S, which share an identical N-terminal domain, are present in cells. XBP-1S is a transcription activator while XBP-1U is the inactive isoform. Although the transactivation domain of XBP-1S has been identified within the XBP-1S-specific C-terminus, molecular mechanism of the transcriptional activation by XBP-1S still remains unknown. Here we report the interaction between p300/CBP-associated factor (PCAF) and XBP-1S through the C-terminal domain of XBP-1S. No binding between XBP-1U and PCAF is detected. In a cell-based reporter assay, overexpression of PCAF further stimulates the XBP-1S-mediated cellular and HTLV-1 transcription while knockdown of PCAF exhibits the opposite effect. Expression of endogenous XBP-1S cellular target genes, such as BiP and CHOP, is significantly inhibited when PCAF is knocked down. Furthermore, PCAF is recruited to the promoters of XBP-1S target genes in vivo, in a XBP-1S-dependent manner. Collectively, our results demonstrate that PCAF mediates the XBP-1S-dependent transcription through the interaction with XBP-1S.
has issue date	2010-09-04(xsd:dateTime)
bibo:doi	10.1093/nar/gkq785
bibo:pmid	20817929
has license	cc-by-nc
sha1sum (hex)	ac29d39e0b59cf2d1469af974756f5efbf3c26dd
schema:url	https://doi.org/10.1093/nar/gkq785
resource representing a document's title	PCAF interacts with XBP-1S and mediates XBP-1S-dependent transcription
has PubMed Central identifier	PMC3025546
has PubMed identifier	20817929
schema:publication	Nucleic Acids Res
resource representing a document's body	covid:ac29d39e0b59cf2d1469af974756f5efbf3c26dd#body_text
is schema:about of	named entity 'C-TERMINUS' named entity 'HUMAN T-LYMPHOTROPIC VIRUS TYPE 1' named entity 'ISOFORM' named entity 'RESULTS' named entity 'REPORT' named entity 'TARGET' named entity 'INTERACTION' named entity 'C-TERMINAL' named entity 'ASSOCIATED' named entity 'REQUIRED' named entity 'A CELL' named entity 'ENDOGENOUS' named entity 'HOST CELL' named entity 'OVEREXPRESSION' named entity 'UNKNOWN' named entity 'INACTIVE' named entity 'DOMAIN' named entity 'PCAF' named entity 'MOLECULAR MECHANISM' named entity 'FACTOR' named entity 'IN VIVO' named entity 'IDENTIFIED' named entity 'VIRUSES' named entity 'VIRUS' named entity 'GENES' named entity 'HERE' named entity 'CHOP' named entity 'KEY' named entity 'transactivation domain' named entity 'PCAF' named entity 'UPR' named entity 'PCAF' named entity 'HTLV-1' named entity 'C-terminal domain' named entity 'transcription' named entity 'PCAF' named entity 'EXPRESSION' named entity 'TRANSCRIPTION' named entity 'RECENTLY' named entity 'REVEALED' named entity 'OUR' named entity 'PCAF' named entity 'XBP-1S' named entity 'TRANSCRIPTION' named entity 'N-TERMINAL ' named entity 'TRANSCRIPTIONAL ACTIVATION' named entity 'PRESENT' named entity 'IDENTICAL' named entity 'EXHIBITS' named entity 'XBP-1U' named entity 'XBP-1S' named entity 'DEPENDENT' named entity 'P300' named entity 'CELLULAR' named entity 'TRANSCRIPTIONAL REGULATION' named entity 'X-BOX BINDING PROTEIN 1' named entity 'MEDIATES' named entity 'BIP' named entity 'DETECTED' named entity 'TRANSACTIVATION' named entity 'PROMOTERS' named entity 'MEDIATED' named entity 'IS A' named entity 'CELLS' named entity 'HTLV-1' named entity 'DEPENDENT' named entity 'XBP-1' named entity 'XBP' named entity 'INHIBITED' named entity 'INVOLVEMENT' named entity 'PLASMA CELL DIFFERENTIATION' named entity 'OPPOSITE' named entity 'BASED' named entity 'SHARE'

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