About: Rousettus aegyptiacus Bats Do Not Support Productive Nipah Virus Replication

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Rousettus aegyptiacus Bats Do Not Support Productive Nipah Virus Replication
Creator	Letko, Michael Munster, Vincent Bushmaker, Trenton Saturday, Greg Meade-White, Kimberly Broder, Christopher Laing, Eric Seifert, Stephanie Van Doremalen, Neeltje
Source	Medline; PMC
abstract	Nipah virus (NiV) is a bat-borne zoonotic pathogen that can cause severe respiratory distress and encephalitis upon spillover into humans. Nipah virus is capable of infecting a broad range of hosts including humans, pigs, ferrets, dogs, cats, hamsters, and at least 2 genera of bats. Little is known about the biology of NiV in the bat reservoir. In this study, we evaluate the potential for the Egyptian fruit bat (EFB), Rousettus aegyptiacus, to serve as a model organism for studying NiV in bats. Our data suggest that NiV does not efficiently replicate in EFBs in vivo. Furthermore, we show a lack of seroconversion against NiV glycoprotein and a lack of viral replication in primary and immortalized EFB-derived cell lines. Our data show that despite using a conserved target for viral entry, NiV replication is limited in some bat species. We conclude that EFBs are not an appropriate organism to model NiV infection or transmission in bats.
has issue date	2019-11-04(xsd:dateTime)
bibo:doi	10.1093/infdis/jiz429
bibo:pmid	31682727
has license	no-cc
sha1sum (hex)	ac4d5ac50a155a3beb6d21e48048e7af05a7df3a
schema:url	https://doi.org/10.1093/infdis/jiz429
resource representing a document's title	Rousettus aegyptiacus Bats Do Not Support Productive Nipah Virus Replication
has PubMed Central identifier	PMC7199784
has PubMed identifier	31682727
schema:publication	J Infect Dis
resource representing a document's body	covid:ac4d5ac50a155a3beb6d21e48048e7af05a7df3a#body_text
is schema:about of	named entity 'respiratory distress' named entity 'biology' named entity 'infecting' named entity 'Our' named entity 'studying' named entity 'infection' named entity 'humans' named entity 'bats' named entity 'NiV' named entity 'target' named entity 'replication' named entity 'NiV' named entity 'NiV' named entity 'serve' named entity 'Nipah virus' named entity 'NiV' named entity 'limited' named entity 'viral replication' named entity 'encephalitis' named entity 'Virus' named entity 'bat' named entity 'NiV' named entity 'EFBs' named entity 'EFB' named entity 'viral entry' named entity 'model organism' named entity 'bat' named entity 'Nipah Virus' named entity 'Little' named entity 'DMEM' named entity 'cell line' named entity 'AAALAC' named entity 'southeast Asia' named entity 'AVL' named entity 'EFBs' named entity 'NiV' named entity 'Egyptian fruit bat' named entity 'Journal of Infectious Diseases' named entity 'NiV' named entity 'histopathology' named entity 'necropsy' named entity 'cell lines' named entity 'kidney' named entity 'viral RNA' named entity 'Institutional Animal Care and Use Committee' named entity 'Thermo Fisher Scientific' named entity 'bat' named entity 'Virus' named entity 'inoculated' named entity 'enzootic transmission' named entity 'NiV' named entity 'EFB' named entity 'mmol/L' named entity 'ephrin-B3' named entity 'serum' named entity 'serum' named entity 'NiV' named entity 'Berlin' named entity 'biosafety level' named entity 'EFBs' named entity 'Fruit bats' named entity 'EFB' named entity 'amino acid' named entity 'virus' named entity 'immunobiology' named entity 'L-glutamine' named entity 'NiV' named entity 'Rocky Mountain Laboratories' named entity 'coronavirus' named entity 'machine learning' named entity 'EFBs' named entity 'viral replication' named entity 'antigen'

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