About: Patient-Based Transcriptome-Wide Analysis Identify Interferon and Ubiquination Pathways as Potential Predictors of Influenza A Disease Severity

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About: Patient-Based Transcriptome-Wide Analysis Identify Interferon and Ubiquination Pathways as Potential Predictors of Influenza A Disease Severity Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Patient-Based Transcriptome-Wide Analysis Identify Interferon and Ubiquination Pathways as Potential Predictors of Influenza A Disease Severity
Creator	Farrar, Jeremy Tolfvenstam, Thomas Hibberd, Martin Lin, Raymond Sangsajja, Chariya De Jong, Menno Chotpitayasunondh, Tawee Wertheim, Heiman Puthavathana, Pilaipan Chokephaibulkit, Kulkanya Chuchottaworn, Chareon Fox, Annette Manosuthi, Weerawat Sansayunh, Piamlarp Suntarattiwong, Piyarat Tambayah, Paul Ha, Tuan Hoang, Long Khor, Chiea Nghiem, Ngoc Ong, Swee Ooi, Eng Rogier Van Doorn, H Thi, Anh Ho, Pei Naim, Mohamed Nazri, Ahmand Nguyen, Vinh Tran, Ngoc Van, Chau Xin, Eliza
Source	Medline; PMC
abstract	BACKGROUND: The influenza A virus is an RNA virus that is responsible for seasonal epidemics worldwide with up to five million cases of severe illness and 500,000 deaths annually according to the World Health Organization estimates. The factors associated with severe diseases are not well defined, but more severe disease is more often seen among persons aged >65 years, infants, pregnant women, and individuals of any age with underlying health conditions. METHODOLOGY/PRINCIPAL FINDINGS: Using gene expression microarrays, the transcriptomic profiles of influenza-infected patients with severe (N = 11), moderate (N = 40) and mild (N = 83) symptoms were compared with the febrile patients of unknown etiology (N = 73). We found that influenza-infected patients, regardless of their clinical outcomes, had a stronger induction of antiviral and cytokine responses and a stronger attenuation of NK and T cell responses in comparison with those with unknown etiology. More importantly, we found that both interferon and ubiquitination signaling were strongly attenuated in patients with the most severe outcomes in comparison with those with moderate and mild outcomes, suggesting the protective roles of these pathways in disease pathogenesis. CONCLUSION/SIGNIFICANCES: The attenuation of interferon and ubiquitination pathways may associate with the clinical outcomes of influenza patients.
has issue date	2014-11-03(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0111640
bibo:pmid	25365328
has license	cc-by
sha1sum (hex)	ac52347e640db03cb8dfaf1f0228caf47570ddaa
schema:url	https://doi.org/10.1371/journal.pone.0111640
resource representing a document's title	Patient-Based Transcriptome-Wide Analysis Identify Interferon and Ubiquination Pathways as Potential Predictors of Influenza A Disease Severity
has PubMed Central identifier	PMC4218794
has PubMed identifier	25365328
schema:publication	PLoS One
resource representing a document's body	covid:ac52347e640db03cb8dfaf1f0228caf47570ddaa#body_text
is schema:about of	named entity 'TRANSCRIPTOME' named entity 'stronger' covid:arg/ac52347e640db03cb8dfaf1f0228caf47570ddaa named entity 'REGARDLESS' named entity '500' named entity 'HEALTH CONDITIONS' named entity 'ACCORDING' named entity 'WELL DEFINED' named entity 'RESPONSIBLE' named entity 'WORLD HEALTH ORGANIZATION' named entity 'ASSOCIATED WITH' named entity 'USING' named entity 'SEASONAL' named entity 'WORLDWIDE' named entity 'THEIR' named entity 'ROLES' named entity 'COMPARISON' named entity 'UBIQUITINATION' named entity 'UP TO' named entity 'INDIVIDUALS' named entity 'COMPARED' named entity 'THESE' named entity 'YEARS' named entity 'INTERFERON ' named entity 'CYTOKINE ' named entity 'ANNUALLY' named entity 'ESTIMATES' named entity 'ANTIVIRAL' named entity 'METHODOLOGY' named entity 'ILLNESS' named entity 'SEVERE DISEASE' named entity 'SEVERE' named entity 'PREGNANT WOMEN' named entity 'UNDERLYING' named entity '40%' named entity 'AGED' named entity 'PATHWAYS' named entity 'POTENTIAL' named entity 'PATIENTS' named entity 'MILD' named entity 'BUT' named entity 'DISEASE' named entity 'INFLUENZA' named entity 'INFECTED' named entity 'AGE' named entity 'DISEASES' named entity 'T CELL' named entity 'OUTCOMES' named entity 'IDENTIFY' named entity 'PATIENT' named entity 'INTERFERON '

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