About: The Interplay between Dengue Virus and the Human Innate Immune System: A Game of Hide and Seek

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About: The Interplay between Dengue Virus and the Human Innate Immune System: A Game of Hide and Seek Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The Interplay between Dengue Virus and the Human Innate Immune System: A Game of Hide and Seek
Creator	Chatel-Chaix, Laurent Freppel, Wesley Tremblay, Nicolas Sow, Aïssatou
Source	Medline; PMC
abstract	With 40% of the world population at risk, infections with dengue virus (DENV) constitute a serious threat to public health. While there is no antiviral therapy available against this potentially lethal disease, the efficacy of the only approved vaccine is not optimal and its safety has been recently questioned. In order to develop better vaccines based on attenuated and/or chimeric viruses, one must consider how the human immune system is engaged during DENV infection. The activation of the innate immunity through the detection of viruses by cellular sensors is the first line of defence against those pathogens. This triggers a cascade of events which establishes an antiviral state at the cell level and leads to a global immunological response. However, DENV has evolved to interfere with the innate immune signalling at multiple levels, hence dampening antiviral responses and favouring viral replication and dissemination. This review elaborates on the interplay between DENV and the innate immune system. A special focus is given on the viral countermeasure mechanisms reported over the last decade which should be taken into consideration during vaccine development.
has issue date	2019-10-10(xsd:dateTime)
bibo:doi	10.3390/vaccines7040145
bibo:pmid	31658677
has license	cc-by
sha1sum (hex)	ac8b5e9b4a49a1062eddf4fc48a19778e66e9a78
schema:url	https://doi.org/10.3390/vaccines7040145
resource representing a document's title	The Interplay between Dengue Virus and the Human Innate Immune System: A Game of Hide and Seek
has PubMed Central identifier	PMC6963221
has PubMed identifier	31658677
schema:publication	Vaccines (Basel)
resource representing a document's body	covid:ac8b5e9b4a49a1062eddf4fc48a19778e66e9a78#body_text
is schema:about of	named entity 'vaccine' named entity 'chimeric' named entity 'optimal' named entity 'Seek' named entity 'GAME' named entity 'LETHAL' named entity 'CASCADE' named entity 'RESPONSES' named entity 'LINE' named entity 'HOW' named entity 'REVIEW' named entity 'ANTIVIRAL' named entity 'SAFETY' named entity 'TRIGGERS' named entity 'CHIMERIC' named entity 'PATHOGENS' named entity 'GLOBAL' named entity 'VACCINE' named entity 'VACCINES' named entity 'RECENTLY' named entity 'GIVEN' named entity 'ANTIVIRAL THERAPY' named entity 'HUMAN' named entity 'IMMUNE' named entity 'WORLD' named entity 'SIGNALLING' named entity 'CONSIDER' named entity 'APPROVED' named entity 'INTERFERE' named entity 'SPECIAL' named entity 'DISEASE' named entity 'EVENTS' named entity 'DENGUE VIRUS' named entity 'HUMAN' named entity 'TAKEN' named entity 'ACTIVATION' named entity 'VIRAL REPLICATION' named entity 'FOCUS' named entity 'INFECTIONS' named entity 'REPORTED' named entity 'EVOLVED' named entity 'IMMUNE SYSTEM' named entity 'ITS' named entity 'ORDER' named entity 'DISSEMINATION' named entity 'INNATE IMMUNE SYSTEM' named entity 'HIDE' named entity 'DENGUE VIRUS' named entity 'PUBLIC HEALTH' named entity 'MECHANISMS' named entity 'EFFICACY' named entity 'DECADE' named entity 'INFECTION' named entity 'LEVEL' named entity 'AVAILABLE' named entity 'VIRAL' named entity 'MULTIPLE' named entity 'CONSIDERATION' named entity 'BASED' named entity 'OPTIMAL' named entity 'IMMUNOLOGICAL RESPONSE' named entity 'BETTER' named entity 'STATE' named entity 'INNATE IMMUNITY' named entity 'THE CELL' named entity 'LEADS' named entity 'LEVELS' named entity 'THREAT' named entity 'VIRUSES' named entity 'DETECTION' named entity 'VACCINE DEVELOPMENT' named entity '40%' named entity 'POPULATION AT RISK' named entity 'COUNTERMEASURE' named entity 'SENSORS' named entity 'ATTENUATED' named entity 'ENGAGED' named entity 'INNATE IMMUNE SYSTEM'

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