About: Cells of human aminopeptidase N (CD13) transgenic mice are infected by human coronavirus-229E in vitro, but not in vivo

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About: Cells of human aminopeptidase N (CD13) transgenic mice are infected by human coronavirus-229E in vitro, but not in vivo Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Cells of human aminopeptidase N (CD13) transgenic mice are infected by human coronavirus-229E in vitro, but not in vivo
Creator	Levis, R Wentworth, David Holmes, Kathryn Shapiro, L Bullis, B Hemmila, E Lerman, I Tresnan, D Turner, B
topic	covid:acb4dc547e62543c5f8abe911ccc4f98821a2af2#this
Source	Elsevier; Medline; PMC
abstract	Abstract Aminopeptidase N, or CD13, is a receptor for serologically related coronaviruses of humans, pigs, and cats. A mouse line transgenic for the receptor of human coronavirus-229E (HCoV-229E) was created using human APN (hAPN) cDNA driven by a hAPN promoter. hAPN-transgenic mice expressed hAPN mRNA in the kidney, small intestine, liver, and lung. hAPN protein was specifically expressed on epithelial cells of the proximal convoluted renal tubules, bronchi, alveolar sacs, and intestinal villi. The hAPN expression pattern within transgenic mouse tissues matched that of mouse APN and was similar in mice heterozygous or homozygous for the transgene. Primary embryonic cells and bone marrow dendritic cells derived from hAPN-transgenic mice also expressed hAPN protein. Although hAPN-transgenic mice were resistant to HCoV-229E in vivo, primary embryonic cells and bone marrow dendritic cells were infected in vitro. hAPN-transgenic mice are valuable as a source of primary mouse cells expressing hAPN. This hAPN-transgenic line will also be used for crossbreeding experiments with other knockout, immune deficient, or transgenic mice to identify factors, in addition to hAPN, that are required for HCoV-229E infection.
has issue date	2005-05-10(xsd:dateTime)
bibo:doi	10.1016/j.virol.2005.02.023
bibo:pmid	15840518
has license	els-covid
sha1sum (hex)	acb4dc547e62543c5f8abe911ccc4f98821a2af2
schema:url	https://doi.org/10.1016/j.virol.2005.02.023
resource representing a document's title	Cells of human aminopeptidase N (CD13) transgenic mice are infected by human coronavirus-229E in vitro, but not in vivo
has PubMed Central identifier	PMC7111747
has PubMed identifier	15840518
schema:publication	Virology
resource representing a document's body	covid:acb4dc547e62543c5f8abe911ccc4f98821a2af2#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/acb4dc547e62543c5f8abe911ccc4f98821a2af2
is schema:about of	named entity 'BUT' named entity 'protein' named entity 'lung' named entity 'mice' named entity 'CD13' named entity 'dendritic cells' named entity 'mice' named entity 'primary' named entity '229E' named entity 'EPITHELIAL CELLS' named entity 'PIGS' named entity 'EMBRYONIC CELLS' named entity 'DEFICIENT' named entity 'EXPERIMENTS' named entity 'ALVEOLAR' named entity 'CATS' named entity 'TRANSGENIC MICE' named entity 'BONE MARROW' named entity 'DRIVEN' named entity 'TRANSGENIC' named entity 'KNOCKOUT' named entity 'MOUSE' named entity 'HCOV-229E' named entity 'TO IDENTIFY' named entity 'DERIVED' named entity 'HETEROZYGOUS' named entity 'IMMUNE' named entity 'CELLS' named entity 'AMINOPEPTIDASE N' named entity 'KIDNEY' named entity 'PRIMARY' named entity 'INFECTION' named entity 'MATCHED' named entity 'TRANSGENIC MOUSE' named entity 'USING' named entity 'HUMAN' named entity 'MRNA' named entity 'CDNA' named entity 'MICE' named entity 'IS A' named entity 'RENAL TUBULES' named entity 'CD13' named entity 'RESISTANT TO' named entity 'SACS' named entity 'RECEPTOR' named entity 'LIVER' named entity 'PROMOTER' named entity 'PROTEIN ' named entity 'TRANSGENIC MICE' named entity 'HOMOZYGOUS' named entity 'DENDRITIC CELLS' named entity 'REQUIRED' named entity 'HUMANS' named entity 'IN VIVO' named entity 'HUMAN' named entity 'USED' named entity 'SMALL INTESTINE' named entity 'PROTEIN' named entity 'A MOUSE' named entity 'CELLS' named entity 'EXPRESSION PATTERN' named entity 'SIMILAR' named entity 'CORONAVIRUSES' named entity 'INFECTED' named entity 'CREATED' named entity 'TRANSGENE' named entity 'APN' named entity 'RELATED' named entity 'CONVOLUTED' named entity 'TISSUES' named entity 'IN VITRO'

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