About: Vaccinia Virus as a Master of Host Shutoff Induction: Targeting Processes of the Central Dogma and Beyond

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Vaccinia Virus as a Master of Host Shutoff Induction: Targeting Processes of the Central Dogma and Beyond
Creator	Yang, Zhilong Dhungel, Pragyesh Cantu, Fernando Molina, Joshua
Source	Medline; PMC
abstract	The synthesis of host cell proteins is adversely inhibited in many virus infections, whereas viral proteins are efficiently synthesized. This phenomenon leads to the accumulation of viral proteins concurrently with a profound decline in global host protein synthesis, a phenomenon often termed “host shutoff”. To induce host shutoff, a virus may target various steps of gene expression, as well as pre- and post-gene expression processes. During infection, vaccinia virus (VACV), the prototype poxvirus, targets all major processes of the central dogma of genetics, as well as pre-transcription and post-translation steps to hinder host cell protein production. In this article, we review the strategies used by VACV to induce host shutoff in the context of strategies employed by other viruses. We elaborate on how VACV induces host shutoff by targeting host cell DNA synthesis, RNA production and processing, mRNA translation, and protein degradation. We emphasize the topics on VACV’s approaches toward modulating mRNA processing, stability, and translation during infection. Finally, we propose avenues for future investigations, which will facilitate our understanding of poxvirus biology, as well as fundamental cellular gene expression and regulation mechanisms.
has issue date	2020-05-21(xsd:dateTime)
bibo:doi	10.3390/pathogens9050400
bibo:pmid	32455727
has license	cc-by
sha1sum (hex)	ace2a35cc2406ef4288bee6a35ab31ca632709cf
schema:url	https://doi.org/10.3390/pathogens9050400
resource representing a document's title	Vaccinia Virus as a Master of Host Shutoff Induction: Targeting Processes of the Central Dogma and Beyond
has PubMed Central identifier	PMC7281567
has PubMed identifier	32455727
schema:publication	Pathogens
resource representing a document's body	covid:ace2a35cc2406ef4288bee6a35ab31ca632709cf#body_text
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