About: Multiple organ infection and the pathogenesis of SARS

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About: Multiple organ infection and the pathogenesis of SARS Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Multiple organ infection and the pathogenesis of SARS
Creator	Zhuang, Hui Fang, Weigang Gao, Dongshia Gao, Zifen Gong, Encong Gu, Jiang He, Zhongpin Li, Xingwang Pei, Fei Shao, Hongquan Shi, Xeying Wang, Shenglan Wu, Bingquan Xie, Zhigang Xu, Danzhen Zhan, Jun Zhang, Bo Zheng, Jie Zhong, Haohao Zhong, Yanfeng Zou, Wanzhong Anderson, Virginia Leong, Y
Source	Medline; PMC
abstract	After >8,000 infections and >700 deaths worldwide, the pathogenesis of the new infectious disease, severe acute respiratory syndrome (SARS), remains poorly understood. We investigated 18 autopsies of patients who had suspected SARS; 8 cases were confirmed as SARS. We evaluated white blood cells from 22 confirmed SARS patients at various stages of the disease. T lymphocyte counts in 65 confirmed and 35 misdiagnosed SARS cases also were analyzed retrospectively. SARS viral particles and genomic sequence were detected in a large number of circulating lymphocytes, monocytes, and lymphoid tissues, as well as in the epithelial cells of the respiratory tract, the mucosa of the intestine, the epithelium of the renal distal tubules, the neurons of the brain, and macrophages in different organs. SARS virus seemed to be capable of infecting multiple cell types in several organs; immune cells and pulmonary epithelium were identified as the main sites of injury. A comprehensive theory of pathogenesis is proposed for SARS with immune and lung damage as key features.
has issue date	2005-08-01(xsd:dateTime)
bibo:doi	10.1084/jem.20050828
bibo:pmid	16043521
has license	cc-by-nc-sa
sha1sum (hex)	acec6ab753cc4f3bdc2dd1e9b63d3ae8e32a3bae
schema:url	https://doi.org/10.1084/jem.20050828
resource representing a document's title	Multiple organ infection and the pathogenesis of SARS
has PubMed Central identifier	PMC2213088
has PubMed identifier	16043521
schema:publication	J Exp Med
resource representing a document's body	covid:acec6ab753cc4f3bdc2dd1e9b63d3ae8e32a3bae#body_text
is schema:about of	named entity 'ORGAN' named entity 'EPITHELIAL CELLS' named entity 'CASES' named entity 'VIRAL PARTICLES' named entity 'THEORY' named entity 'MUCOSA' named entity 'CONFIRMED' named entity 'PATHOGENESIS' named entity 'INVESTIGATED' named entity 'KEY' named entity 'FEATURES' named entity 'LARGE' named entity 'STAGES' named entity 'SITES' named entity 'COMPREHENSIVE' named entity 'IDENTIFIED' named entity 'MAIN' named entity 'MULTIPLE' named entity 'CELL TYPES' named entity 'ANALYZED' named entity 'IMMUNE CELLS' named entity 'MACROPHAGES' named entity 'CIRCULATING' named entity 'INTESTINE' named entity 'NUMBER OF' named entity 'NEW' named entity 'injury' named entity 'organs' named entity 'investigated' named entity 'multiple' named entity 'pathogenesis' named entity 'SARS' named entity 'SUSPECTED' named entity 'DEATHS' named entity 'IMMUNE' named entity 'MULTIPLE' covid:arg/acec6ab753cc4f3bdc2dd1e9b63d3ae8e32a3bae named entity 'ARTICLE' named entity 'RENAL' named entity '700' named entity 'LYMPHOCYTES' named entity 'THE BRAIN' named entity 'VARIOUS' named entity 'LYMPHOCYTE COUNTS' named entity 'DETECTED' named entity 'ORGANS' named entity 'PATHOGENESIS' named entity '415' named entity 'INFECTING' named entity 'GENOMIC SEQUENCE' named entity 'INFECTIOUS DISEASE' named entity 'PULMONARY EPITHELIUM' named entity 'INFECTIONS' named entity 'CAPABLE' named entity 'EVALUATED' named entity 'INFECTION' named entity 'NEURONS' named entity 'DAMAGE' named entity 'T LYMPHOCYTE'

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