About: Synthesis, antimicrobial, anticancer, antiviral evaluation and QSAR studies of 4-(1-aryl-2-oxo-1,2-dihydro-indol-3-ylideneamino)-N-substituted benzene sulfonamides

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About: Synthesis, antimicrobial, anticancer, antiviral evaluation and QSAR studies of 4-(1-aryl-2-oxo-1,2-dihydro-indol-3-ylideneamino)-N-substituted benzene sulfonamides Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Synthesis, antimicrobial, anticancer, antiviral evaluation and QSAR studies of 4-(1-aryl-2-oxo-1,2-dihydro-indol-3-ylideneamino)-N-substituted benzene sulfonamides
Creator	De Clercq, Erik Narasimhan, Balasubramanian Kumar, Mahesh Mani, Vasudevan Ramasamy, Kalavathy Bakar, Abu Majeed, Abdul Alam, Puncak Kumar Mishra, Rakesh
Source	Elsevier; PMC
abstract	Abstract A series of 4-(1-aryl-2-oxo-1,2-dihydro-indol-3-ylideneamino)-N-substituted benzenesulfonamide derivatives (1–32) was synthesized and evaluated for its in vitro antimicrobial, antiviral and cytotoxic activities. Antimicrobial results indicated that compounds (11) and (18) were found to be the most effective ones. In general, the synthesized compounds were bacteriostatic and fungistatic in their action. The cytotoxic screening results indicated that the compounds were less active than the standard drug 5-fluorouracil (5-FU). None of the compounds inhibited viral replication at subtoxic concentrations. In general, the presence of a pyrimidine ring with electron releasing groups and an ortho- and para-substituted benzoyl moiety favored antimicrobial activities. The results of QSAR studies demonstrated the importance of topological parameters, valence zero order molecular connectivity index (0 χ v ) and valence first order molecular connectivity index (1 χ v ) in describing the antimicrobial activity of synthesized compounds.
has issue date	2014-09-30(xsd:dateTime)
bibo:doi	10.1016/j.arabjc.2012.12.005
has license	els-covid
sha1sum (hex)	ad1624d9afb9e2f803a2c573a7b4a17767beaa23
schema:url	https://doi.org/10.1016/j.arabjc.2012.12.005
resource representing a document's title	Synthesis, antimicrobial, anticancer, antiviral evaluation and QSAR studies of 4-(1-aryl-2-oxo-1,2-dihydro-indol-3-ylideneamino)-N-substituted benzene sulfonamides
has PubMed Central identifier	PMC7185680
schema:publication	Arabian Journal of Chemistry
resource representing a document's body	covid:ad1624d9afb9e2f803a2c573a7b4a17767beaa23#body_text
is schema:about of	named entity 'ELECTRON' named entity '5-FLUOROURACIL' named entity 'CYTOTOXIC' named entity 'RELEASING' named entity 'INDOL' named entity 'ACTION' named entity 'BENZENE' named entity 'VIRAL REPLICATION' named entity 'PRESENCE OF' named entity 'ITS' named entity 'FOUND' named entity 'INHIBITED' named entity 'PARA' named entity 'CONCENTRATIONS' named entity 'SULFONAMIDES' named entity 'OXO' named entity 'SYNTHESIS' named entity 'QSAR' named entity 'SERIES' named entity 'BENZENESULFONAMIDE' named entity 'ORTHO-' named entity 'PYRIMIDINE' named entity '2818' named entity 'GROUPS' named entity 'EFFECTIVE' named entity 'EVALUATION' named entity 'HOSTING' named entity 'STUDIES' named entity 'PRODUCTION' named entity 'ANTIVIRAL' named entity 'ANTICANCER' named entity 'INDOL' named entity 'DRUG' named entity 'GENERAL' named entity 'INDICATED' named entity 'ACTIVITIES' named entity 'IN VITRO' named entity 'ACTIVE' named entity 'BENZOYL' named entity 'RESULTS' named entity 'ANTIVIRAL' named entity 'STANDARD' named entity 'SCREENING' named entity 'RING' named entity 'MOIETY' named entity 'ANTIMICROBIAL' named entity 'THEIR' named entity 'SYNTHESIZED' named entity 'OXO' named entity 'ANTIMICROBIAL' named entity 'EVALUATED' covid:arg/ad1624d9afb9e2f803a2c573a7b4a17767beaa23 named entity 'antimicrobial' named entity 'ortho' named entity 'antiviral' named entity 'oxo' named entity 'antimicrobial activities' named entity 'standard drug' named entity 'sulfonamides' named entity 'antimicrobial' named entity 'antiviral' named entity 'steric' named entity 'linear free energy relationship' named entity 'Coxsackie virus' named entity '5-fluorouracil' named entity 'HOMO' named entity 'MBC' named entity 'HIV-1' named entity 'electron' named entity 'antibacterial' named entity 'electron' named entity 'biological activity' named entity 'fungicidal' named entity 'antifungal' named entity 'toxicity'

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