About: Lactate dehydrogenase and susceptibility to deterioration of mild COVID-19 patients: a multicenter nested case-control study

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About: Lactate dehydrogenase and susceptibility to deterioration of mild COVID-19 patients: a multicenter nested case-control study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Lactate dehydrogenase and susceptibility to deterioration of mild COVID-19 patients: a multicenter nested case-control study
Creator	Sun, Feng Li, Yang Zhang, Wenhong Xu, Bin Shao, Lingyun Ai, Jing-Wen Zhou, Xian Jiang, Xiangao Shi, Jichan Wu, Zhengxing Ye, Xinchun Yu, Hongying Zhang, Haocheng Zhang, Qiran
Source	Medline; PMC
abstract	BACKGROUND: Coronavirus disease 2019 (COVID-19) has infected more than 4 million people within 4 months. There is an urgent need to properly identify high-risk cases that are more likely to deteriorate even if they present mild diseases on admission. METHODS: A multicenter nested case-control study was conducted in four designated hospitals in China enrolling confirmed COVID-19 patients who were mild on admission. Baseline clinical characteristics were compared between patients with stable mild illness (stable mild group) and those who deteriorated from mild to severe illness (progression group). RESULTS: From Jan 17, 2020, to Feb 1, 2020, 85 confirmed COVID-19 patients were enrolled, including 16 in the progression group and 69 in the stable mild group. Compared to stable mild group (n = 69), patients in the progression group (n = 16) were more likely to be older, male, presented with dyspnea, with hypertension, and with higher levels of lactase dehydrogenase and c-reactive protein. In multivariate logistic regression analysis, advanced age (odds ratio [OR], 1.012; 95% confidence interval [CI], 1.020–1.166; P = 0.011) and the higher level of lactase dehydrogenase (OR, 1.012; 95% CI, 1.001–1.024; P = 0.038) were independently associated with exacerbation in mild COVID-19 patients. CONCLUSION: Advanced age and high LDH level are independent risk factors for exacerbation in mild COVID-19 patients. Among the mild patients, clinicians should pay more attention to the elderly patients or those with high LDH levels.
has issue date	2020-06-03(xsd:dateTime)
bibo:doi	10.1186/s12916-020-01633-7
bibo:pmid	32493370
has license	cc-by
sha1sum (hex)	ad1d307ed1cd7fa0c95cf52a969d607aa7b92f81
schema:url	https://doi.org/10.1186/s12916-020-01633-7
resource representing a document's title	Lactate dehydrogenase and susceptibility to deterioration of mild COVID-19 patients: a multicenter nested case-control study
has PubMed Central identifier	PMC7268591
has PubMed identifier	32493370
schema:publication	BMC Med
resource representing a document's body	covid:ad1d307ed1cd7fa0c95cf52a969d607aa7b92f81#body_text
is schema:about of	named entity 'group' named entity 'COVID-19' named entity 'mild' named entity 'c-reactive protein' named entity 'progression' named entity 'cases' named entity 'IDENTIFY' named entity 'RESULTS' named entity 'ASSOCIATED WITH' named entity 'LIKELY' named entity 'PATIENTS' named entity 'MILD' named entity 'CLINICAL CHARACTERISTICS' named entity 'COVID-19' named entity 'HIGH-RISK' named entity 'CONFIRMED' named entity 'MONTHS' named entity 'multicenter' named entity 'diseases' named entity 'Methods' named entity 'mild' named entity 'male' named entity 'hospitals' named entity 'mild' named entity 'compared' named entity 'lactase' named entity 'lactase' named entity 'Coronavirus disease 2019' named entity 'clinical characteristics' named entity 'odds ratio' named entity '95% confidence interval' named entity 'China' named entity 'independently' named entity 'COVID' named entity 'CT scan' named entity 'LDH' named entity 'demographic' named entity 'prognosis' named entity 'septic shock' named entity 'C-reactive protein' named entity '95% confidence interval' named entity 'mortality rate' named entity 'SPSS' named entity 'dyspnea' named entity 'LDH' named entity 'lungs' named entity 'receptor' named entity '8 days' named entity 'diagnostic procedures' named entity 'LDH' named entity '4.25' named entity 'binding receptor' named entity 'WHO' named entity 'cytokine' named entity 'acute respiratory distress syndrome' named entity 'epidemiological' named entity 'virus' named entity 'WHO' named entity 'hazard ratio' named entity 'Huashan Hospital' named entity 'symptom' named entity 'MERS-CoV' named entity 'nested case-control study' named entity 'lactase' named entity 'logistic regression model' named entity 'risk factors' named entity 'virus' named entity 'angiotensin converting enzyme 2'

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