About: Generation of a Broadly Cross-Neutralizing Antibody Fragment against Several Mexican Scorpion Venoms

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About: Generation of a Broadly Cross-Neutralizing Antibody Fragment against Several Mexican Scorpion Venoms Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Generation of a Broadly Cross-Neutralizing Antibody Fragment against Several Mexican Scorpion Venoms
Creator	Becerril, Baltazar Fernández-Taboada, Guillermo Gómez-Ramírez, Ilse Ledezma-Candanoza, Luis Olamendi-Portugal, Timoteo Possani, Lourival Remi Rodríguez-Rodríguez, Everardo Riaño-Umbarila, Lidia
Source	PMC
abstract	The recombinant antibody fragments generated against the toxic components of scorpion venoms are considered a promising alternative for obtaining new antivenoms for therapy. Using directed evolution and site-directed mutagenesis, it was possible to generate a human single-chain antibody fragment with a broad cross-reactivity that retained recognition for its original antigen. This variant is the first antibody fragment that neutralizes the effect of an estimated 13 neurotoxins present in the venom of nine species of Mexican scorpions. This single antibody fragment showed the properties of a polyvalent antivenom. These results represent a significant advance in the development of new antivenoms against scorpion stings, since the number of components would be minimized due to their broad cross-neutralization capacity, while at the same time bypassing animal immunization.
has issue date	2019-01-10(xsd:dateTime)
bibo:doi	10.3390/toxins11010032
bibo:pmid	30634620
has license	cc-by
sha1sum (hex)	ad552caeace5008fba0e156d30a5e6f8f6c2f420
schema:url	https://doi.org/10.3390/toxins11010032
resource representing a document's title	Generation of a Broadly Cross-Neutralizing Antibody Fragment against Several Mexican Scorpion Venoms
has PubMed Central identifier	PMC6356842
has PubMed identifier	30634620
schema:publication	Toxins (Basel)
resource representing a document's body	covid:ad552caeace5008fba0e156d30a5e6f8f6c2f420#body_text
is schema:about of	named entity 'SCORPION VENOMS' named entity 'TOXINS' named entity 'ANTIVENOM' named entity 'ITS' named entity 'VENOM' named entity 'MEXICAN' named entity 'ANTIBODY FRAGMENT' named entity 'TIME' named entity 'ADVANCE' named entity 'DUE TO' named entity 'IMMUNIZATION' named entity 'ANTIBODY FRAGMENT' named entity 'SINGLE' named entity 'TOXIC' named entity 'SINGLE-CHAIN ANTIBODY' named entity 'DEVELOPMENT' named entity 'RECOGNITION' named entity 'GENERATION' named entity 'MEXICAN SCORPION' named entity 'CROSS' named entity 'NEUTRALIZING ANTIBODY' named entity 'REPRESENT' named entity 'SCORPION VENOMS' named entity 'THESE' named entity 'NEUROTOXINS' named entity 'SCORPIONS' named entity 'BYPASSING' named entity 'VARIANT' named entity 'HUMAN' named entity 'SITE-DIRECTED MUTAGENESIS' named entity 'SPECIES' named entity 'PRESENT' named entity 'REACTIVITY' named entity 'POSSIBLE' named entity 'NEW' named entity 'USING' named entity 'ALTERNATIVE' named entity 'COMPONENTS' named entity 'ORIGINAL' named entity 'CROSS' named entity 'ANTIGEN' named entity 'NUMBER OF' named entity 'GENERATE' named entity 'DIRECTED EVOLUTION' named entity 'CAPACITY' named entity 'PROPERTIES' named entity 'ANIMAL' named entity 'THEIR' named entity 'SCORPION STINGS' named entity 'GENERATED' named entity 'EFFECT' named entity 'RETAINED' named entity 'CONSIDERED' named entity 'ANTIVENOMS' named entity 'BROAD' named entity 'RESULTS' named entity 'FOR THERAPY' named entity 'RECOMBINANT ANTIBODY' named entity 'FRAGMENTS' named entity 'ESTIMATED' named entity 'SIGNIFICANT' covid:arg/ad552caeace5008fba0e156d30a5e6f8f6c2f420 named entity 'scorpion stings' named entity 'antibody' named entity 'scorpion venoms' named entity 'single-chain' named entity 'immunization' named entity 'recombinant antibody' named entity 'Scorpion Venoms' named entity 'Neutralizing Antibody' named entity 'venom' named entity 'toxin' named entity 'mutagenesis' named entity 'cross-reactivity'

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