About: Possible role of HLA class-I genotype in SARS-CoV-2 infection and progression: A pilot study in a cohort of Covid-19 Spanish patients

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About: Possible role of HLA class-I genotype in SARS-CoV-2 infection and progression: A pilot study in a cohort of Covid-19 Spanish patients Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Possible role of HLA class-I genotype in SARS-CoV-2 infection and progression: A pilot study in a cohort of Covid-19 Spanish patients
Creator	Luis, José Org, Alabau, Castañer Alarcón, Nieves De, Ana Ganan@salud, Israel García-Soidán, Ana Gañán, Israel Iturrieta-Zuazo, Ignacio Nieto Gañán, Israel Pariente Rodríguez, Roberto Pintos-Fonseca, Malet Rita, Claudia Serrano Villar, Sergio Tejeda Velarde, Amalia
Source	Elsevier; Medline; PMC
abstract	Human Leukocyte Antigen (HLA) includes a large set of genes with important actions in immune response against viral infection. Numerous studies have revealed the existence of significant associations between certain HLA alleles and the susceptibility and prognosis of different infectious diseases. In this pilot study we analyse the binding affinity between 66 class I HLA alleles and SARS-CoV-2 viral peptides, and its association with the severity of the disease. A total of 45 Spanish patients with mild, moderate and severe SARS-CoV-2 infection were typed for HLA class I; after that, we analysed if an in silico model of HLA I-viral peptide binding affinity and classical HLA supertypes could be correlated to the severity of the disease. Our results suggest that patients with mild disease present Class I HLA molecules with a higher theoretical capacity for binding SARS-Cov-2 peptides and showed greater heterozygosity when comparing them with moderate and severe groups. In this regard, identifying HLA-SARS-CoV-2 peptides binding differences between individuals would help to clarify the heterogeneity of clinical responses to the disease and will also be useful to guide a personalized treatment according to its particular risk.
has issue date	2020-08-15(xsd:dateTime)
bibo:doi	10.1016/j.clim.2020.108572
bibo:pmid	32810602
has license	no-cc
sha1sum (hex)	adad815eb1b852ddeb1b8a955ea3433d7bd81eb4
schema:url	https://doi.org/10.1016/j.clim.2020.108572
resource representing a document's title	Possible role of HLA class-I genotype in SARS-CoV-2 infection and progression: A pilot study in a cohort of Covid-19 Spanish patients
has PubMed Central identifier	PMC7428760
has PubMed identifier	32810602
schema:publication	Clin Immunol
resource representing a document's body	covid:adad815eb1b852ddeb1b8a955ea3433d7bd81eb4#body_text
is schema:about of	named entity 'peptides' named entity 'set of genes' named entity 'Nucleic Acids' named entity 'peptides' named entity 'HLA' named entity 'SARS-CoV-2' named entity 'infection' named entity 'viral infection' named entity 'peptides' named entity 'pilot study' named entity 'Covid' named entity 'pilot study' named entity 'class I HLA' named entity 'heterogeneity' named entity 'HLA' named entity 'infection' named entity 'SARS-CoV-2' named entity 'Covid' named entity 'SARS-CoV-2' named entity 'immune response' named entity 'Allele frequency' named entity 'HLA' named entity 'MHC' named entity 'HLA' named entity 'heterozygosity' named entity 'epitopes' named entity 'binding affinity' named entity 'HLA' named entity 'SARS-CoV-2' named entity 'prognosis' named entity 'binding affinity' named entity 'personalized treatment' named entity 'infectious diseases' named entity 'infection' named entity 'alleles' named entity 'genotype' covid:arg/adad815eb1b852ddeb1b8a955ea3433d7bd81eb4 named entity 'RESULTS' named entity 'CLASSICAL' named entity 'N A' named entity 'MODEL OF' named entity 'THEORETICAL' named entity 'CORRELATED' named entity 'INCLUDES' named entity 'TO GUIDE' named entity 'MHC CLASS I' named entity 'CAPACITY' named entity 'RES' named entity 'CLARIFY' named entity 'SPANISH' named entity 'REVEALED' named entity 'BINDING AFFINITY' named entity 'BINDING' named entity 'HLA' named entity 'PRE' named entity 'PATIENTS' named entity 'PILOT STUDY ' named entity 'SARS-COV-2 INFECTION' named entity 'PROOF' named entity 'GENOTYPE' named entity 'JOURNAL ' named entity 'CLASS' named entity 'PROGRESSION' named entity 'HLA' named entity 'HLA' named entity 'SARS-CoV-2' named entity 'KIR'

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