About: Cytokine cascade and networks among MSM HIV seroconverters: implications for early immunotherapy

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About: Cytokine cascade and networks among MSM HIV seroconverters: implications for early immunotherapy Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Cytokine cascade and networks among MSM HIV seroconverters: implications for early immunotherapy
Creator	Liu, Lihong Wang, Pengfei Li, Zhen Chen, Hui Li, Ning Wu, Hao Su, Bin Zhang, Tong Li, Lan Huang, Xiaojie Li, Haiying Liu, Xinchao Meyers, Kathrine
topic	covid:adc882dda7e73073791ae83afee7affd0d3e3793#this
source	Medline; PMC
abstract	The timing, intensity and duration of the cytokine cascade and reorganized interrelations in cytokine networks are not fully understood during acute HIV-1 infection (AHI). Using sequential plasma samples collected over three years post-infection in a cohort of MSM HIV-1 seroconvertors, we determined the early kinetics of cytokine levels during FiebigI-IV stages using Luminex-based multiplex assays. Cytokines were quantified and relationships between cytokines were assessed by Spearman correlation. Compared with HIV-negative MSM, HIV-infected individuals had significantly increased multiple plasma cytokines, including GM-CSF, IFN-α2, IL-12p70, IP-10 and VEGF, during both acute and chronic stages of infection. Furthermore, rapid disease progressors (RDPs) had earlier and more robust cytokine storms, compared with slow disease progressors (SDPs) (49.6 days vs. 74.9 days, respectively; 6.7-fold vs. 3.7-fold change of cytokines, respectively), suggesting the faster and stronger cytokine storm during AHI could promote disease progression. On the other hand, HIV-1 infection induced more interlocked cytokines network, establishing new strong correlations and imposing a higher rigidity. There were, respectively, 146 (44.9%) statistically significant correlations of cytokines in RDPs and 241 (74.2%) in SDPs (p < 0.001). This study suggests that immunomodulatory interventions aimed at controlling cytokine storm in AHI may be beneficial to slow eventual disease progression.
has issue date	2016-11-10(xsd:dateTime)
bibo:doi	10.1038/srep36234
bibo:pmid	27830756
has license	cc-by
sha1sum (hex)	adc882dda7e73073791ae83afee7affd0d3e3793
schema:url	https://doi.org/10.1038/srep36234
resource representing a document's title	Cytokine cascade and networks among MSM HIV seroconverters: implications for early immunotherapy
has PubMed Central identifier	PMC5103227
has PubMed identifier	27830756
schema:publication	Sci Rep
resource representing a document's body	covid:adc882dda7e73073791ae83afee7affd0d3e3793#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/adc882dda7e73073791ae83afee7affd0d3e3793
is schema:about of	named entity 'INCREASED' named entity 'SUGGEST' named entity 'INFECTED' named entity 'AHI' named entity 'GM-CSF' named entity 'LIMITING' named entity 'POST' named entity 'DOUBLE' named entity 'GROWING' named entity 'ROLE' named entity 'ACUTE HIV INFECTION' named entity 'T CELL' named entity 'DYNAMIC' named entity 'KINETICS' named entity 'USING' named entity 'STATISTICALLY SIGNIFICANT' named entity 'TIMING' named entity 'DETERMINED' named entity 'MSM' named entity 'HIV-1' named entity 'NATURAL' named entity 'DURATION' named entity 'BENEFICIAL' named entity 'DIVERSITY' named entity 'UNDERSTOOD' named entity 'ANTIVIRAL' named entity 'GENES' named entity 'FIGHTING' named entity 'PRODUCTION' named entity 'POTENTIAL' named entity 'NETWORKS' named entity 'REPORTS' named entity 'BASED' named entity 'IFN' named entity 'HAND' named entity '28P' named entity 'COMPARED' named entity 'SPECIFIC IMMUNITY' named entity 'TO PRODUCE' named entity 'STUDIES' named entity 'PROMOTE' named entity 'CYTOKINE STORM' named entity 'CYTOKINE LEVELS' named entity 'VIRAL PERSISTENCE' named entity 'STAGES' named entity 'POINTS' named entity 'ACUTE' named entity 'ROBUST' named entity 'INITIAL' named entity 'PLASMA' named entity 'CASCADE' named entity 'MACROPHAGES' named entity 'SLOW' named entity 'THESE' named entity 'cytokine' named entity 'Some' named entity 'chronic' named entity 'HIV-1 infection' named entity 'acute HIV infection' named entity 'slow' named entity 'production' named entity 'strong' named entity 'immune system' named entity 'cytokines' named entity 'progressors' named entity 'unity' named entity 'type'

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