About: Viral and Cellular mRNA Translation in Coronavirus-Infected Cells

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Viral and Cellular mRNA Translation in Coronavirus-Infected Cells
Creator	Makino, S Lokugamage, K Nakagawa, K
Source	Elsevier; Medline; PMC
abstract	Coronaviruses have large positive-strand RNA genomes that are 5′ capped and 3′ polyadenylated. The 5′-terminal two-thirds of the genome contain two open reading frames (ORFs), 1a and 1b, that together make up the viral replicase gene and encode two large polyproteins that are processed by viral proteases into 15–16 nonstructural proteins, most of them being involved in viral RNA synthesis. ORFs located in the 3′-terminal one-third of the genome encode structural and accessory proteins and are expressed from a set of 5′ leader-containing subgenomic mRNAs that are synthesized by a process called discontinuous transcription. Coronavirus protein synthesis not only involves cap-dependent translation mechanisms but also employs regulatory mechanisms, such as ribosomal frameshifting. Coronavirus replication is known to affect cellular translation, involving activation of stress-induced signaling pathways, and employing viral proteins that affect cellular mRNA translation and RNA stability. This chapter describes our current understanding of the mechanisms involved in coronavirus mRNA translation and changes in host mRNA translation observed in coronavirus-infected cells.
has issue date	2016-01-01(xsd:dateTime)
bibo:doi	10.1016/bs.aivir.2016.08.001
bibo:pmid	27712623
has license	bronze-oa
sha1sum (hex)	ae194b78b6f3d826b801096efc8f7d4f3c720c39
schema:url	https://doi.org/10.1016/bs.aivir.2016.08.001
resource representing a document's title	Viral and Cellular mRNA Translation in Coronavirus-Infected Cells
has PubMed Central identifier	PMC5388242
has PubMed identifier	27712623
schema:publication	Advances in Virus Research
resource representing a document's body	covid:ae194b78b6f3d826b801096efc8f7d4f3c720c39#body_text
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