About: Two deletion variants of Middle East respiratory syndrome coronavirus found in a patient with characteristic symptoms

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About: Two deletion variants of Middle East respiratory syndrome coronavirus found in a patient with characteristic symptoms Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Two deletion variants of Middle East respiratory syndrome coronavirus found in a patient with characteristic symptoms
Creator	Ke, Changwen Wu, Jie Su, Juan Cao, Yujuan He, Mingliang Wan, Chengsong Wu, Xianbo Xie, Qian Zhang, Bao Zhao, Wei Changwen Ke, • Wu, • Zhang, •
Source	Medline; PMC
abstract	Significant sequence variation of Middle East respiratory syndrome coronavirus (MERS CoV) has never been detected since it was first reported in 2012. A MERS patient came from Korea to China in late May 2015. The patient was 44 years old and had symptoms including high fever, dry cough with a little phlegm, and shortness of breath, which are roughly consistent with those associated with MERS, and had had close contact with individuals with confirmed cases of MERS.After one month of therapy with antiviral, anti-infection, and immune-enhancing agents, the patient recovered in the hospital and was discharged. A nasopharyngeal swab sample was collected for direct sequencing, which revealed two deletion variants of MERS CoV. Deletions of 414 and 419 nt occurred between ORF5 and the E protein, resulting in a partial protein fusion or truncation of ORF5 and the E protein. Functional analysis by bioinformatics and comparison to previous studies implied that the two variants might be defective in their ability to package MERS CoV. However, the mechanism of how these deletions occurred and what effects they have need to be further investigated. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00705-017-3361-x) contains supplementary material, which is available to authorized users.
has issue date	2017-04-18(xsd:dateTime)
bibo:doi	10.1007/s00705-017-3361-x
bibo:pmid	28421366
has license	cc-by
sha1sum (hex)	ae423f7ae98fa3e8a1249bd193df1c09bdeedf7c
schema:url	https://doi.org/10.1007/s00705-017-3361-x
resource representing a document's title	Two deletion variants of Middle East respiratory syndrome coronavirus found in a patient with characteristic symptoms
has PubMed Central identifier	PMC5506503
has PubMed identifier	28421366
schema:publication	Arch Virol
resource representing a document's body	covid:ae423f7ae98fa3e8a1249bd193df1c09bdeedf7c#body_text
is schema:about of	named entity 'SYMPTOMS' named entity 'patient' named entity 'dry cough' named entity 'therapy' named entity 'breath' named entity 'Middle East respiratory syndrome' named entity 'deletion' named entity '2015' named entity 'CONTACT WITH' named entity 'SIGNIFICANT' named entity 'INDIVIDUALS' named entity 'LATE' named entity 'INCLUDING' named entity 'CHINA' named entity 'YEARS' named entity 'PHLEGM' named entity 'ASSOCIATED WITH' named entity 'CONSISTENT WITH' named entity 'MERS' named entity 'OLD' named entity 'MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS' named entity 'MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS' named entity 'ONE MONTH' named entity 'HIGH FEVER' named entity 'CHARACTERISTIC' named entity 'FOUND' named entity 'PATIENT' named entity 'CAME' named entity 'VARIANTS' named entity 'DELETION' named entity 'SHORTNESS OF BREATH' named entity 'A LITTLE' named entity 'CONFIRMED' named entity 'CASES' named entity 'THERAPY' named entity 'SEQUENCE VARIATION' named entity 'PATIENT' named entity 'KOREA' named entity 'SYMPTOMS' named entity 'REPORTED' named entity 'DRY COUGH' named entity 'NEVER' named entity 'DETECTED' named entity '2015' named entity 'cases' named entity 'May' named entity 'detected' named entity 'symptoms' named entity 'phlegm' named entity 'sequence variation' named entity 'MERS' named entity 'Middle East respiratory syndrome coronavirus' named entity 'N-terminal' named entity 'transmembrane domain' named entity 'hydrophobic' named entity 'deletions' named entity 'SARS-CoV' named entity 'protein' named entity 'contigs' named entity 'nasopharyngeal swab' named entity 'RNA' named entity 'cloned' named entity 'genomic sequences' named entity 'recombination' named entity 'transmembrane domain' named entity 'protein' named entity 'RNA' named entity 'Protein sequences' named entity 'cDNA'

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