About: Age-related dynamics of constitutive cytokine transcription levels of feline monocytes

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Age-related dynamics of constitutive cytokine transcription levels of feline monocytes Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Age-related dynamics of constitutive cytokine transcription levels of feline monocytes
Creator	Kipar, A Lutz, H Meli, M Reinacher, M Baptiste, K Barth, A Knietsch, M
topic	covid:ae7c17a3391248d9583a7e8e6ef31da0621add81#this
Source	Elsevier; Medline; PMC
abstract	Monocytes/macrophages are central mediators of inflammation and immunity and therefore of major interest in the study of immunosenescence. In healthy adult cats, monocytes have been shown to constitutively transcribe pro- and anti-inflammatory cytokines. However, in order to characterize the effect of age, feline monocyte functions were examined for changes in cytokine transcription levels in early stages of immunosenescence. For this purpose, isolated, short-term cultured monocytes from barrier-maintained adult cats of different ages (15 mo to 10 yr) were examined for transcription of IL-1β, IL-6, IL-10, IL-12 p40 and TNF-α by real-time PCR. Transcription levels of cytokines varied and were generally highest for IL-1β. For IL-1β, IL-6 and IL-12 p40, both young and old cats exhibited highest levels. The age association was significant. TNF-α appeared to be transcribed at similar levels over the examination period, whereas IL-10 tended to decline with age but without any statistical significant differences. The observed age association of the constitutive transcription of some cytokines indicates a drop in monocyte activities from youth to middle age, which is then followed by a (progressive) increase with increasing age. This provides evidence that monocytes are in part responsible for the pro-inflammatory status observed with ageing.
has issue date	2005-01-18(xsd:dateTime)
bibo:doi	10.1016/j.exger.2004.12.007
bibo:pmid	15763402
has license	no-cc
sha1sum (hex)	ae7c17a3391248d9583a7e8e6ef31da0621add81
schema:url	https://doi.org/10.1016/j.exger.2004.12.007
resource representing a document's title	Age-related dynamics of constitutive cytokine transcription levels of feline monocytes
has PubMed Central identifier	PMC7119058
has PubMed identifier	15763402
schema:publication	Exp Gerontol
resource representing a document's body	covid:ae7c17a3391248d9583a7e8e6ef31da0621add81#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/ae7c17a3391248d9583a7e8e6ef31da0621add81
is schema:about of	named entity 'MONOCYTES' named entity 'real-time PCR' named entity 'adult' named entity 'isolated' named entity 'All rights reserved' named entity 'monocytes' named entity 'TRANSCRIPTION' named entity 'ASSOCIATION' named entity 'ANTI-INFLAMMATORY' named entity 'CENTRAL' named entity 'AGES' named entity 'DECLINE' named entity 'IL-10' named entity 'AGE' named entity 'STUDY' named entity 'SHORT-TERM' named entity 'PROVIDES' named entity 'TRANSCRIBED' covid:arg/ae7c17a3391248d9583a7e8e6ef31da0621add81 named entity 'IMMUNITY' named entity 'MONOCYTE' named entity 'OBSERVED' named entity 'DYNAMICS' named entity 'CYTOKINE ' named entity 'RELATED' named entity 'AGE' named entity 'FELINE' named entity 'LEVELS' named entity 'INC' named entity 'ORDER' named entity 'PURPOSE' named entity 'HIGHEST' named entity 'CULTURED' named entity 'STATISTICAL' named entity 'FOLLOWED BY' named entity 'ISOLATED' named entity 'TO CHARACTERIZE' named entity 'INFLAMMATORY' named entity 'RIGHTS' named entity 'EFFECT' named entity 'INCREASING' named entity 'IMMUNOSENESCENCE' named entity 'PERIOD' named entity 'HEALTHY ADULT' named entity 'YOUTH' named entity 'DIFFERENT' named entity 'SIMILAR' named entity 'MAINTAINED' named entity 'MAJOR' named entity 'LEVELS' named entity 'YOUNG' named entity 'IL-1B' named entity 'CATS' named entity 'EXAMINED FOR' named entity 'EVIDENCE' named entity 'FUNCTIONS' named entity 'SIGNIFICANT' named entity 'GENERALLY' named entity 'TRANSCRIPTION' named entity 'OLD' named entity 'MIDDLE AGE' named entity 'BUT' named entity 'CONSTITUTIVE TRANSCRIPTION' named entity 'MONOCYTES' named entity 'INCREASE' named entity '10%' named entity 'ADULT' named entity 'DROP' named entity 'TNF-A' named entity 'BARRIER' named entity 'CHANGES' named entity 'CYTOKINE ' named entity 'RESPONSIBLE'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software