About: Heat-treated virus inactivation rate depends strongly on treatment procedure

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Heat-treated virus inactivation rate depends strongly on treatment procedure
Creator	Munster, Vincent Fischer, Robert Lloyd-Smith, James Gamble, Amandine Morris, Dylan Yinda, Kwe
Source	BioRxiv; Medline; PMC
abstract	Decontamination of objects and surfaces can limit transmission of infectious agents via fomites or biological samples. It is required for the safe re-use of potentially contaminated personal protective equipment and medical and laboratory equipment. Heat treatment is widely used for the inactivation of various infectious agents, notably viruses. We show that for liquid specimens (here suspension of SARS-CoV-2 in cell culture medium), virus inactivation rate under heat treatment at 70°C can vary by almost two orders of magnitude depending on the treatment procedure, from a half-life of 0.86 min (95% credible interval: [0.09, 1.77]) in closed vials in a heat block to 37.0 min ([12.65, 869.82]) in uncovered plates in a dry oven. These findings suggest a critical role of evaporation in virus inactivation using dry heat. Placing samples in open or uncovered containers may dramatically reduce the speed and efficacy of heat treatment for virus inactivation. Heating procedures must be carefully specified when reporting experimental studies to facilitate result interpretation and reproducibility, and carefully considered when designing decontamination guidelines.
has issue date	2020-08-10(xsd:dateTime)
bibo:doi	10.1101/2020.08.10.242206
bibo:pmid	32793913
has license	cc-by-nc-nd
sha1sum (hex)	ae961d28f469038d5b31a41ed644b00477d919ee
schema:url	https://doi.org/10.1101/2020.08.10.242206
resource representing a document's title	Heat-treated virus inactivation rate depends strongly on treatment procedure
has PubMed Central identifier	PMC7425175
has PubMed identifier	32793913
schema:publication	bioRxiv
resource representing a document's body	covid:ae961d28f469038d5b31a41ed644b00477d919ee#body_text
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