About: Human bocavirus in the nasopharynx of otitis-prone children

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Human bocavirus in the nasopharynx of otitis-prone children
Creator	Nokso-Koivisto, Johanna Toivola, Hanna Korpela, Riitta Lehtoranta, Liisa Sö Derlund-Venermo, Maria Blomgren, Karin Hatakka, Katja Pitkä Ranta, Anne Poussa, Tuija
source	Elsevier; Medline; PMC
abstract	Abstract Objectives Human bocavirus (HBoV) is frequently identified in children with respiratory tract infections, and its role in acute otitis media (AOM) has been suggested. The disease associations for the closely related bocaviruses HBoV2-4 remain unknown. Increasing evidence shows that probiotics may reduce the risk of AOM of viral origin. Objectives of the study was to examine the prevalence and persistence of bocaviruses in consecutive nasopharyngeal samples (NPS) of otitis-prone children, and whether an association exists between HBoV and the child's characteristics, respiratory symptoms, and AOM pathogens, and whether probiotics reduce the occurrence of HBoV. Methods In a double-blind, placebo-controlled, randomized, 6-month intervention study, 269 otitis-prone children (aged 9 months to 5.6 years), consumed daily either one capsule of probiotics (Lactobacillus rhamnosus GG, L. rhamnosus Lc705, Bifidobacterium breve 99 and Propionibacterium freudenreichii JS) or placebo. After a clinical examination and NPS collected at three-time points, the presence and persistence of HBoV1-4 DNA in NPS was determined by RT-qPCR at the baseline, after 3, and 6 months. Results A high load (>10,000copies/ml) of HBoV DNA was detected in 26 (17.1%) of 152 children, and 16 (10.5%) showed a prolonged presence of HBoV for at least 3 months. None had DNA of HBoV2-4. Higher number of siblings associated with increased HBoV prevalence (p =0.029). Prevalence or persistence of HBoV was not significantly associated with other characteristics, respiratory symptoms, or AOM pathogens. Probiotic intervention significantly reduced the number of HBoV DNA-positive samples (probiotic vs. placebo: 6.4% vs. 19.0%, OR=0.25, CI 95%=0.07–0.94, p =0.039). Conclusions HBoV, but not HBoV2-4, DNA occurs often in the nasopharynx of otitis-prone children, and may persist for 3–6 months. Probiotic treatment possibly reduced the presence of HBoV.
has issue date	2012-02-29(xsd:dateTime)
bibo:doi	10.1016/j.ijporl.2011.10.025
bibo:pmid	22119148
has license	els-covid
sha1sum (hex)	ae9e3663f5d54898189a6b1de0141edd12a955a5
schema:url	https://doi.org/10.1016/j.ijporl.2011.10.025
resource representing a document's title	Human bocavirus in the nasopharynx of otitis-prone children
has PubMed Central identifier	PMC7172510
has PubMed identifier	22119148
schema:publication	International Journal of Pediatric Otorhinolaryngology
resource representing a document's body	covid:ae9e3663f5d54898189a6b1de0141edd12a955a5#body_text
is schema:about of	named entity 'nasopharynx' named entity 'pacifier' named entity 'infection' named entity 'signs and symptoms' named entity 'pathogens' named entity 'upper airways' named entity '5.6' named entity 'respiratory symptoms' named entity '95%' named entity 'statistically significant' named entity 'Human bocavirus' named entity 'Lactobacillus rhamnosus GG' named entity 'Human bocavirus' named entity 'clinical examination' named entity 'S. pneumoniae' named entity 'Germany' named entity 'fever' named entity 'alternative therapy' named entity 'SPSS' named entity 'L. rhamnosus GG' named entity 'AOM' named entity 'AOM' named entity '2.2' named entity 'logistic regression' named entity 'primary infection' named entity 'pathogens' named entity 'upper respiratory tract infections' named entity 'L. rhamnosus GG' named entity 'cough' named entity 'nasopharynx' named entity 'cough' named entity 'bacterial pathogens' named entity 'infectious diseases' named entity 'serodiagnosis' named entity '95%' named entity 'rhinovirus' named entity 'genome' named entity 'Qiagen' named entity 'enteroviruses' named entity 'upper airways' named entity 'mucus' named entity 'mucosal' named entity 'Probiotic' named entity 'infection' named entity 'infection' named entity 'L. rhamnosus GG' named entity 'probiotic' named entity 'Streptococcus pneumoniae' named entity 'respiratory symptoms' named entity 'Bifidobacterium breve' named entity 'PCR' named entity 'Serological testing' named entity 'AOM' named entity 'virus' named entity 'Probiotic' named entity 'S. pneumoniae' named entity 'H. influenzae' named entity 'Haemophilus influenzae' named entity 'etiology' named entity 'infection' named entity 'otitis' named entity 'L. rhamnosus' named entity 'post hoc test' named entity 'respiratory symptoms' named entity 'L. rhamnosus' named entity 'respiratory symptoms' named entity 'probiotic' named entity 'AOM' named entity 'otitis' named entity 'Probiotic' named entity 'nasopharynx' named entity 'statistically significant' named entity 'odds ratios'

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