About: The Nucleolus: Structure and Function

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The Nucleolus: Structure and Function
Creator	Boisvert, François-Michel Dubois, Marie-Line
Source	PMC
abstract	The nucleolus is the largest nuclear organelle and is the primary site of ribosome subunit biogenesis in eukaryotic cells. It is assembled around arrays of ribosomal DNA genes, forming specific chromosomal features known as nucleolar organizing regions (NORs) which are the sites of ribosomal DNA transcription. While the nucleolus main activity involve different steps of ribosome biogenesis, the presence of proteins with no obvious relationship with ribosome subunit production suggests additional functions for the nucleolus, such as regulation of mitosis, cell cycle progression, stress response and biogenesis of multiple ribonucleoprotein complexes. The many novel factors and separate classes of proteins identified within the nucleolus support this view that the nucleolus may perform additional functions beyond its known role in ribosome subunit biogenesis. Here we review our knowledge of the nucleolar functions and will provide a detailed picture of how the nucleolus is involved in many cellular pathways.
has issue date	2016-04-23(xsd:dateTime)
bibo:doi	10.1007/978-3-319-38882-3_2
has license	no-cc
sha1sum (hex)	aeaa398d8fae0e991d01b60cef4544041a00bd60
schema:url	https://doi.org/10.1007/978-3-319-38882-3_2
resource representing a document's title	The Nucleolus: Structure and Function
has PubMed Central identifier	PMC7123373
schema:publication	The Functional Nucleus
resource representing a document's body	covid:aeaa398d8fae0e991d01b60cef4544041a00bd60#body_text
is schema:about of	named entity 'nucleolus' named entity 'While' named entity 'additional functions' named entity 'Nucleolus' named entity 'CELL CYCLE PROGRESSION' named entity 'CHROMOSOMAL' named entity 'ITS' named entity 'SPECIFIC' named entity 'RELATIONSHIP' named entity 'OBVIOUS' named entity 'COMPLEXES' named entity 'NUCLEOLUS' named entity 'REVIEW' named entity 'BIOGENESIS' named entity 'NOVEL' named entity 'ACTIVITY' named entity 'KNOWLEDGE' named entity 'REGULATION OF MITOSIS' named entity 'STRESS RESPONSE' named entity 'OUR' named entity 'STEPS' named entity 'ROLE' named entity 'PATHWAYS' named entity 'DNA TRANSCRIPTION' named entity 'RIBONUCLEOPROTEIN' named entity 'FUNCTION' named entity 'STRUCTURE' named entity 'RIBOSOME BIOGENESIS' named entity 'FEATURES' named entity 'PERFORM' named entity 'PRODUCTION' named entity 'CELLULAR' named entity 'CLASSES' named entity 'HERE' named entity 'DETAILED' named entity 'KNOWN' named entity 'BEYOND' named entity 'RIBOSOMAL DNA' named entity 'REGIONS' named entity 'PRIMARY SITE' named entity 'NUCLEOLUS' named entity 'NUCLEOLAR' named entity 'HOW' named entity 'RIBOSOME SUBUNIT' named entity 'VIEW' named entity 'MULTIPLE' named entity 'INVOLVED' named entity 'SEPARATE' named entity 'IDENTIFIED' named entity 'ORGANIZING' named entity 'DIFFERENT' named entity 'SUPPORT' named entity 'PROVIDE' named entity 'LARGEST' named entity 'PICTURE' named entity '2C CELL' named entity 'GENES' named entity 'SITE OF' named entity 'PRESENCE OF' named entity 'FUNCTIONS' named entity 'PROTEINS' named entity 'MAIN' named entity 'ADDITIONAL' named entity 'NUCLEAR ORGANELLE' named entity 'EUKARYOTIC CELLS' named entity 'FORMING' named entity 'SITES' covid:arg/aeaa398d8fae0e991d01b60cef4544041a00bd60 named entity 'additional functions' named entity 'proteins' named entity 'production' named entity 'progression' named entity 'subunit' named entity 'nucleolar organizing regions' named entity 'eukaryotic cells' named entity 'ribosomal DNA' named entity 'biogenesis' named entity 'nucleolus' named entity 'multiple' named entity 'ribonucleoprotein complexes' named entity 'ribosome' named entity 'nucleolus'

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