About: Immunoreactivity of the central nervous system in cats with a Borna disease-like meningoencephalomyelitis (staggering disease)

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About: Immunoreactivity of the central nervous system in cats with a Borna disease-like meningoencephalomyelitis (staggering disease) Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Immunoreactivity of the central nervous system in cats with a Borna disease-like meningoencephalomyelitis (staggering disease)
Creator	Lindberg, R Lundgren, A.-L Gosztonyi, G Ludwig, -H Ludwig, H
Source	PMC
abstract	The inflammatory cell composition and the expression of major histocompatibility complex (MHC) antigens in the central nervous system (CNS) of 13 cats with a spontaneous, Borna disease-like meningoencephalomyelitis (staggering disease) was investigated by immunohistochemistry with a panel of monoclonal and polyclonal antibodies. T lymphocytes were the predominating inflammatory cells within the adventitial space. CD4(+) T cells were more abundant than CD8(+) T cells. Scattered IgG-, IgA- and IgM-containing cells were found in the adventitial space and surrounding neuropil, often adjacent to neurons. There was a markedly increased MHC class II expression in cells morphologically resembling microglia. In several cats, Borna disease virus specific antigen was detected, but only in a few cells, mainly of macrophage character. Our findings indicate a long-standing inflammatory reaction in the CNS of cats with staggering disease, possibly triggered and sustained by a persistent viral infection.
has issue date	1995-01-01(xsd:dateTime)
bibo:doi	10.1007/bf00294319
bibo:pmid	7484095
has license	no-cc
sha1sum (hex)	aec248d8e59d3b1dbdcfeeaf22c71f677d10138f
schema:url	https://doi.org/10.1007/bf00294319
resource representing a document's title	Immunoreactivity of the central nervous system in cats with a Borna disease-like meningoencephalomyelitis (staggering disease)
has PubMed Central identifier	PMC7086677
has PubMed identifier	7484095
schema:publication	Acta Neuropathol
resource representing a document's body	covid:aec248d8e59d3b1dbdcfeeaf22c71f677d10138f#body_text
is schema:about of	named entity 'microglia' named entity 'CD8' named entity 'CD4' named entity 'major histocompatibility complex (MHC)' named entity 'macrophage' named entity 'Borna' named entity 'immunohistochemistry' named entity 'T lymphocytes' named entity 'FINDINGS' named entity 'MONOCLONAL' covid:arg/aec248d8e59d3b1dbdcfeeaf22c71f677d10138f named entity 'adventitial' named entity 'abundant' named entity 'Our' named entity 'spontaneous' named entity 'space' named entity 'disease' named entity 'neurons' named entity 'antigens' named entity 'CNS' named entity 'morphologically' named entity 'antigen' named entity 'antigens' named entity 'disease' named entity 'necropsy' named entity 'etiology' named entity 'antibody' named entity 'adventitial' named entity 'suppurative' named entity 'CD4' named entity 'small intestine' named entity 'CD8 +' named entity 'BDV' named entity 'immunohistochemistry' named entity 'medulla oblongata' named entity 'horse serum' named entity 'strong immune reaction' named entity 'antigen' named entity 'BDV' named entity 'internal organs' named entity 'necropsy' named entity 'BDV' named entity 'monoclonal antibodies' named entity 'Immunoglobulin' named entity 'formalin' named entity 'BDV' named entity 'immunoglobulins' named entity 'feline immunodeficiency virus' named entity 'antigenic' named entity 'encephalomyelitis' named entity 'MHC class II' named entity 'CNS' named entity 'CNS' named entity 'antigen' named entity 'flow cytometry' named entity 'antigen-presenting' named entity 'immunostaining' named entity 'immunoglobulins' named entity 'macrophages' named entity 'antigen' named entity 'positive controls' named entity 'CNS' named entity 'antibody' named entity 'lymphoid cells' named entity 'protein binding' named entity 'BDV' named entity 'antibody' named entity 'microglial cells' named entity 'antibodies' named entity 'frozen sections' named entity 'antigen' named entity 'Viral infection' named entity 'Formalin-fixed' named entity 'Borna disease' named entity 'macrophages' named entity 'neuron' named entity 'immunohistochemical'

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