About: In vitro antiviral effect of germacrone on feline calicivirus

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About: In vitro antiviral effect of germacrone on feline calicivirus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	In vitro antiviral effect of germacrone on feline calicivirus
Creator	Tian, Jin Liu, Chunguo Wu, Hongxia Liu, Dafei Liandong Qu, • Liu, Yongxiang Sun, Xue Zhang, • Zu, Shaopo
topic	covid:aee2bac97ecff567f6d040080b360dd57a48d979#this
Source	Medline; PMC
abstract	Feline calicivirus (FCV) often causes respiratory tract and oral disease in cats and is a highly contagious virus. Widespread vaccination does not prevent the spread of FCV. Furthermore, the low fidelity of the RNA-dependent RNA polymerase of FCV leads to the emergence of new variants, some of which show increased virulence. Currently, few effective anti-FCV drugs are available. Here, we found that germacrone, one of the main constituents of volatile oil from rhizoma curcuma, was able to effectively reduce the growth of FCV strain F9 in vitro. This compound exhibited a strong anti-FCV effect mainly in the early phase of the viral life cycle. The antiviral effect depended on the concentration of the drug. In addition, germacrone treatment had a significant inhibitory effect against two other reference strains, 2280 and Bolin, and resulted in a significant reduction in the replication of strains WZ-1 and HRB-SS, which were recently isolated in China. This is the first report of antiviral effects of germacrone against a calicivirus, and extensive in vivo research is needed to evaluate this drug as an antiviral therapeutic agent for FCV.
has issue date	2016-03-21(xsd:dateTime)
bibo:doi	10.1007/s00705-016-2825-8
bibo:pmid	26997613
has license	no-cc
sha1sum (hex)	aee2bac97ecff567f6d040080b360dd57a48d979
schema:url	https://doi.org/10.1007/s00705-016-2825-8
resource representing a document's title	In vitro antiviral effect of germacrone on feline calicivirus
has PubMed Central identifier	PMC7087046
has PubMed identifier	26997613
schema:publication	Arch Virol
resource representing a document's body	covid:aee2bac97ecff567f6d040080b360dd57a48d979#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/aee2bac97ecff567f6d040080b360dd57a48d979
is schema:about of	named entity 'GERMACRONE' named entity 'replication' named entity 'antiviral' named entity 'This' named entity 'needed' named entity 'vivo' named entity 'EFFECTIVE' named entity 'ANTIVIRAL' named entity 'HRB' named entity 'PHASE' named entity 'REPORT' named entity 'CURCUMA' named entity 'ORAL DISEASE' named entity 'IN VITRO' named entity 'DRUG' named entity 'VIRAL LIFE CYCLE' named entity 'VOLATILE OIL' named entity 'RESPIRATORY TRACT' named entity 'ONE OF' named entity 'GROWTH' named entity 'VACCINATION' named entity 'INHIBITORY EFFECT' covid:arg/aee2bac97ecff567f6d040080b360dd57a48d979 named entity 'PREVENT THE SPREAD' named entity 'IS A' named entity 'EVALUATE' named entity 'FCV' named entity 'RNA-DEPENDENT RNA POLYMERASE' named entity 'NEW' named entity 'RESEARCH' named entity 'AVAILABLE' named entity 'REDUCE' named entity 'EFFECT' named entity 'FELINE CALICIVIRUS' named entity 'RECENTLY' named entity 'FELINE CALICIVIRUS' named entity 'ISOLATED' named entity 'HIGHLY' named entity 'FOUND' named entity 'VIRUS' named entity 'STRAINS' named entity 'EMERGENCE' named entity 'IN VITRO' named entity 'NEEDED' named entity 'CHINA' named entity 'STRAIN' named entity 'LEADS' named entity 'CURRENTLY' named entity 'CALICIVIRUS' named entity 'DRUGS' named entity 'ANTIVIRAL' named entity 'FIDELITY' named entity 'REPLICATION' named entity 'VARIANTS' named entity 'CATS' named entity 'GERMACRONE' named entity 'WIDESPREAD' named entity 'RHIZOMA' named entity 'IN VIVO' named entity 'MAIN' named entity 'ADDITION' named entity 'LOW' named entity 'DOES NOT' named entity 'EXTENSIVE' named entity 'INCREASED VIRULENCE' named entity 'THERAPEUTIC AGENT' named entity 'REFERENCE' named entity 'HERE' named entity 'CONCENTRATION OF' named entity 'CONSTITUENTS' named entity 'SIGNIFICANT'

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