About: Identification of SARS-CoV-2 Vaccine Epitopes Predicted to Induce Long-term Population-Scale Immunity

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About: Identification of SARS-CoV-2 Vaccine Epitopes Predicted to Induce Long-term Population-Scale Immunity Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Identification of SARS-CoV-2 Vaccine Epitopes Predicted to Induce Long-term Population-Scale Immunity
Creator	Yarmarkovich, Mark Maris, John Farrel, Alvin Warrington, John
source	Elsevier; Medline; PMC
abstract	Summary Here we propose a SARS-CoV-2 vaccine design concept based on identification of highly conserved regions of the viral genome and newly acquired adaptations, both predicted to generate epitopes presented on MHC class I and II across the vast majority of the population. We further prioritize genomic regions that generate highly dissimilar peptides from the human proteome, and are also predicted to produce B cell epitopes. We propose sixty-five 33mer peptide sequences, a subset of which can be tested using DNA or mRNA delivery strategies. These include peptides that are contained within evolutionarily divergent regions of the spike protein reported to increase infectivity through increased binding to the ACE2 receptor and within a newly evolved furin cleavage site thought to increase membrane fusion. Validation and implementation of this vaccine concept could specifically target specific vulnerabilities of SARS-CoV-2 and should engage a robust adaptive immune response in the vast majority of the population.
has issue date	2020-06-08(xsd:dateTime)
bibo:doi	10.1016/j.xcrm.2020.100036
bibo:pmid	32835302
has license	els-covid
sha1sum (hex)	aefed687fc3c2d833cb0fa175adc6cbfb505b6e2
schema:url	https://doi.org/10.1016/j.xcrm.2020.100036
resource representing a document's title	Identification of SARS-CoV-2 Vaccine Epitopes Predicted to Induce Long-term Population-Scale Immunity
has PubMed Central identifier	PMC7276303
has PubMed identifier	32835302
schema:publication	Cell Rep Med
resource representing a document's body	covid:aefed687fc3c2d833cb0fa175adc6cbfb505b6e2#body_text
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