About: Community prevalence of SARS-CoV-2 virus in England during May 2020: REACT study

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About: Community prevalence of SARS-CoV-2 virus in England during May 2020: REACT study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Community prevalence of SARS-CoV-2 virus in England during May 2020: REACT study
Creator	Riley, Steven Donnelly, Christl Barclay, Wendy Diggle, Peter Walters, Caroline Atchison, Christina Ward, Helen Ainslie, Kylie Ashby, Deborah Cooke, Graham Darzi, Ara Elliott, Paul Taylor, Graham Eales, Oliver Jeffrey, Benjamin
Source	MedRxiv
abstract	Background England has experienced one of the highest rates of confirmed COVID-19 mortality in the world. SARS-CoV-2 virus has circulated in hospitals, care homes and the community since January 2020. Our current epidemiological knowledge is largely informed by clinical cases with far less understanding of community transmission. Methods The REal-time Assessment of Community Transmission (REACT) study is a nationally representative prevalence survey of SARS-CoV-2 virus swab-positivity in the community in England. We recruited participants regardless of symptom status. Results We found 159 positives from 120,610 swabs giving an average prevalence of 0.13% (95% CI: 0.11%,0.15%) from 1st May to 1st June 2020. We showed decreasing prevalence with a halving time of 8.6 (6.2, 13.6) days, implying an overall reproduction number R of 0.57 (0.45, 0.72). Adults aged 18 to 24 yrs had the highest swab-positivity rates, while those >64 yrs had the lowest. Of the 126 participants who tested positive with known symptom status in the week prior to their swab, 39 reported symptoms while 87 did not, giving an estimate that 69% (61%,76%) of people were symptom-free for the 7 days prior testing positive in our community sample. Symptoms strongly associated with swab-positivity were: nausea and/or vomiting, diarrhoea, blocked nose, loss of smell, loss of taste, headache, chills and severe fatigue. Recent contact with a known COVID-19 case was associated with odds of 24 (16, 38) for swab-positivity. Compared with non-key workers, odds of swab-positivity were 7.7 (2.4, 25) among care home (long-term care facilities) workers and 5.2 (2.9, 9.3) among health care workers. However, some of the excess risk associated with key worker status was explained by recent contact with COVID-19 cases. We found no strong evidence for geographical variability in positive swab results. Conclusion Our results provide a reliable baseline against which the impact of subsequent relaxation of lockdown can be assessed to inform future public health efforts to control transmission.
has issue date	2020-07-11(xsd:dateTime)
bibo:doi	10.1101/2020.07.10.20150524
has license	medrxiv
sha1sum (hex)	af130d2559425ade40a4c599340272e56f2ee954
schema:url	https://doi.org/10.1101/2020.07.10.20150524
resource representing a document's title	Community prevalence of SARS-CoV-2 virus in England during May 2020: REACT study
resource representing a document's body	covid:af130d2559425ade40a4c599340272e56f2ee954#body_text
is schema:about of	named entity 'REACT' named entity 'COVID-19' named entity 'CASES' named entity 'COMMUNITY' named entity 'care homes' named entity 'high levels' named entity 'SARS-CoV-2' named entity 'epidemiological' named entity 'COVID' named entity 'community transmission' named entity 'SARS-CoV-2 virus' named entity 'England' named entity 'COVID-19 pandemic' named entity 'severe acute respiratory syndrome coronavirus 2' named entity 'COVID' named entity 'SARS-CoV-2 virus' named entity 'London' named entity 'loss of taste' named entity 'United States' named entity 'care home' named entity 'ethnicity' named entity 'Community Transmission' named entity 'community transmission' named entity 'Public Health England' named entity 'infection' named entity 'chills' named entity 'geographical clustering' named entity 'transport medium' named entity 'care home' named entity 'Logistic regression' named entity 'epidemics' named entity 'tested positive' named entity 'positive test' named entity '3.5' named entity 'general practitioner' named entity '2.2' named entity 'England' named entity '3.5' named entity '95% CI' named entity 'diarrhoea' named entity 'nose and throat' named entity 'rates of infection' named entity 'positive swab' named entity 'nose and throat' named entity 'key worker' named entity 'NHS' named entity 'IRAS' named entity 'care home' named entity 'demographic' named entity 'ethnicity' named entity 'infection' named entity 'reproduction number' named entity 'health care workers' named entity 'cold chain' named entity 'London' named entity 'reproduction number' named entity 'positive swab' named entity 'representative sample' named entity 'infection' named entity 'COVID' named entity 'health care workers' named entity 'generation time' named entity 'SARS-CoV-2' named entity 'PHE' named entity 'key worker' named entity 'exponential decay' named entity 'Children and young people' named entity 'COVID' named entity 'refrigerate' named entity 'binomial distribution' named entity 'AIC'

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