About: Wild-type human coronaviruses prefer cell-surface TMPRSS2 to endosomal cathepsins for cell entry

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About: Wild-type human coronaviruses prefer cell-surface TMPRSS2 to endosomal cathepsins for cell entry Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Wild-type human coronaviruses prefer cell-surface TMPRSS2 to endosomal cathepsins for cell entry
Creator	Matsuyama, Shutoku Shirato, Kazuya Kawase, Miyuki
Source	Elsevier; Medline; PMC
abstract	Abstract Human coronaviruses (HCoVs) enter cells via two distinct pathways: the endosomal pathway using cathepsins to activate spike protein and the cell-surface or early endosome pathway using extracellular proteases such as transmembrane protease serine 2 (TMPRSS2). We previously reported that clinical isolates of HCoV-229E preferred cell-surface TMPRSS2 to endosomal cathepsin for cell entry, and that they acquired the ability to use cathepsin L by repeated passage in cultured cells and were then able to enter cells via the endosomal pathway. Here, we show that clinical isolates of HCoV-OC43 and -HKU1 preferred the cell-surface TMRRSS2 to endosomal cathepsins for cell entry, similar to HCoV-229E. In addition, the cell-culture-adapted HCoV-OC43 lost the ability to infect and replicate in air-liquid interface cultures of human bronchial tracheal epithelial cells. These results suggest that circulating HCoVs in the field generally use cell-surface TMPRSS2 for cell entry, not endosomal cathepsins, in human airway epithelial cells.
has issue date	2018-04-30(xsd:dateTime)
bibo:doi	10.1016/j.virol.2017.11.012
bibo:pmid	29217279
has license	els-covid
sha1sum (hex)	af3259ad6660d4dba31e93b1b924e0a12c82a388
schema:url	https://doi.org/10.1016/j.virol.2017.11.012
resource representing a document's title	Wild-type human coronaviruses prefer cell-surface TMPRSS2 to endosomal cathepsins for cell entry
has PubMed Central identifier	PMC7112029
has PubMed identifier	29217279
schema:publication	Virology
resource representing a document's body	covid:af3259ad6660d4dba31e93b1b924e0a12c82a388#body_text
is schema:about of	named entity 'epithelial cells' named entity 'coronaviruses' named entity 'ability' named entity 'EPITHELIAL CELLS' named entity 'ACTIVATE' named entity 'RESULTS' named entity 'INTERFACE' named entity 'PATHWAYS' named entity 'ADAPTED' named entity 'CULTURED CELLS' named entity 'PROTEIN ' named entity 'PREVIOUSLY' named entity 'ADDITION' named entity 'ENTRY' named entity 'HERE' named entity 'PREFERRED' named entity 'SUGGEST' named entity 'REPEATED' named entity 'CELL' named entity 'ISOLATES' named entity 'DISTINCT' named entity 'CELLS' named entity 'CATHEPSINS' named entity 'EXTRACELLULAR' named entity 'REPLICATE' named entity 'TRANSMEMBRANE PROTEASE SERINE 2' named entity 'TRACHEAL' named entity 'CORONAVIRUSES' named entity 'EARLY ENDOSOME' named entity 'CLINICAL' named entity 'REPORTED' named entity 'CULTURE' named entity 'ENTER' named entity 'IN THE FIELD' named entity 'HCOV-229E' covid:arg/af3259ad6660d4dba31e93b1b924e0a12c82a388 named entity 'TO INFECT' named entity 'GENERALLY' named entity 'ACQUIRED' named entity 'CELL' named entity 'CORONAVIRUSES' named entity 'WILD-TYPE' named entity 'SURFACE' named entity 'CATHEPSINS' named entity 'SURFACE' named entity 'SPIKE PROTEIN' named entity 'CIRCULATING' named entity 'AIRWAY' named entity 'PATHWAY' named entity 'BRONCHIAL' named entity 'HUMAN' named entity 'TMPRSS2' named entity 'USING' named entity 'PROTEASES' named entity 'AIR-LIQUID' named entity 'PASSAGE' named entity 'HCOV-OC43' named entity 'CATHEPSIN' named entity 'USE' named entity 'SIMILAR' named entity 'THESE' named entity 'LOST' named entity 'CATHEPSIN L' named entity 'ENTRY' named entity 'HUMAN' named entity 'TMPRSS2' named entity 'ENDOSOMAL PATHWAY' named entity 'TMPRSS2' named entity 'enter' named entity 'spike' named entity 'preferred' named entity 'ability' named entity 'endosomal' named entity 'cathepsin' named entity 'extracellular' named entity 'endosomal' named entity 'cell entry' named entity 'cell entry' named entity 'endosomal'

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