About: Pathogenesis of Korean Sapelovirus A in piglets and chicks

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About: Pathogenesis of Korean Sapelovirus A in piglets and chicks Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Pathogenesis of Korean Sapelovirus A in piglets and chicks
Creator	Cho, Kyoung-Oh Kim, Deok-Song Lee, Ju-Hwan Park, Jun-Gyu Son, Kyu-Yeol Goodfellow, Ian Baek, Yeong-Bin Cho, Eun-Hyo Choi, Jong-Soon Hosmillo, Myra Kim, Ji-Yun Kwon, Joseph Seo, Ja-Young Soliman, Mahmoud Bak, Geon-Yong Alfajaro, Mia Kang, † Mun-Il
topic	covid:af5f5cae93582ca713bbc2abaea17d7898b63f72#this
Source	PMC
abstract	Sapelovirus A (SV-A), formerly known as porcine sapelovirus as a member of a new genus Sapelovirus, is known to cause enteritis, pneumonia, polioencephalomyelitis and reproductive disorders in pigs. We have recently identified α2,3-linked sialic acid on GD1a ganglioside as a functional SV-A receptor rich in the cells of pigs and chickens. However, the role of GD1a in viral pathogenesis remains elusive. Here, we demonstrated that a Korean SV-A strain could induce diarrhoea and intestinal pathology in piglets but not in chicks. Moreover, this Korean SV-A strain had mild extra-intestinal tropisms appearing as mild, non-suppurative myelitis, encephalitis and pneumonia in piglets, but not in chicks. By real-time reverse transcription (RT) PCR, higher viral RNA levels were detected in faecal samples than in sera or extra-intestinal organs from virus-inoculated piglets. Immunohistochemistry confirmed that high viral antigens were detected in the epithelial cells of intestines from virus-inoculated piglets but not from chicks. This Korean SV-A strain could bind the cultured cell lines originated from various species, but replication occurred only in cells of porcine origin. These data indicated that this Korean SV-A strain could replicate and induce pathology in piglets but not in chicks, suggesting that additional porcine-specific factors are required for virus entry and replication. In addition, this Korean SV-A strain is enteropathogenic, but could spread to the bloodstream from the gut and disseminate to extra-intestinal organs and tissues. These results will contribute to our understanding of SV-A pathogenesis so that efficient anti-sapelovirus drugs and vaccines could be developed in the future.
has issue date	2016-10-13(xsd:dateTime)
bibo:doi	10.1099/jgv.0.000571
bibo:pmid	27487773
has license	cc-by
sha1sum (hex)	af5f5cae93582ca713bbc2abaea17d7898b63f72
schema:url	https://doi.org/10.1099/jgv.0.000571
resource representing a document's title	Pathogenesis of Korean Sapelovirus A in piglets and chicks
has PubMed Central identifier	PMC5078829
has PubMed identifier	27487773
schema:publication	J Gen Virol
resource representing a document's body	covid:af5f5cae93582ca713bbc2abaea17d7898b63f72#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/af5f5cae93582ca713bbc2abaea17d7898b63f72
is schema:about of	named entity 'tropisms' named entity 'Here' named entity 'levels' named entity 'pathogenesis' named entity 'chickens' named entity 'ganglioside' named entity 'strain' named entity 'THESE' named entity 'INTESTINAL' named entity 'DISSEMINATE' named entity 'PORCINE SAPELOVIRUS' named entity 'HIGHER' named entity 'RICH' named entity 'INDUCE' named entity 'SPREAD' named entity 'COULD BE' named entity 'DATA' named entity 'THE GUT' named entity 'CONFIRMED' named entity 'IMMUNOHISTOCHEMISTRY' named entity 'ROLE' named entity 'MEMBER OF' named entity 'HIGH' named entity 'REPRODUCTIVE DISORDERS' named entity 'DETECTED' named entity 'INTESTINES' named entity 'ADDITION' named entity 'LEVELS' named entity 'SPECIFIC' named entity 'CAUSE' named entity 'REQUIRED' named entity 'CHICKS' named entity 'VIRAL RNA' named entity 'RECEPTOR' named entity 'MYELITIS' named entity 'SIALIC ACID' named entity 'SUPPURATIVE' named entity 'PATHOLOGY' named entity 'PCR' named entity 'VIRUS ENTRY' named entity 'PNEUMONIA' named entity 'NON-' named entity 'REVERSE TRANSCRIPTION' named entity 'CULTURED CELL' named entity 'BIND' named entity 'RESULTS' named entity 'DIARRHOEA' named entity 'RECENTLY' named entity 'TISSUES' named entity 'VACCINES' named entity 'UNDERSTANDING' named entity 'SERA' named entity 'REPLICATE' named entity 'MILD' named entity 'PIGS' named entity 'FAECAL' named entity 'PATHOGENESIS' named entity 'VIRUS' named entity 'GD1A GANGLIOSIDE' named entity 'ENTEROPATHOGENIC' named entity 'VIRAL ANTIGENS' named entity 'POLIOENCEPHALOMYELITIS' named entity 'SAPELOVIRUS A'

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