About: Hemophagocytic lymphohistiocytosis: review of etiologies and management

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About: Hemophagocytic lymphohistiocytosis: review of etiologies and management Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Hemophagocytic lymphohistiocytosis: review of etiologies and management
Creator	George, Melissa
Source	Medline; PMC
abstract	Hemophagocytic lymphohistiocytosis (HLH) covers a wide array of related life-threatening conditions featuring ineffective immunity characterized by an uncontrolled hyperinflammatory response. HLH is often triggered by infection. Familial forms result from genetic defects in natural killer cells and cytotoxic T-cells, typically affecting perforin and intracellular vesicles. HLH is likely under-recognized, which contributes to its high morbidity and mortality. Early recognition is crucial for any reasonable attempt at curative therapy to be made. Current treatment regimens include immunosuppression, immune modulation, chemotherapy, and biological response modification, followed by hematopoietic stem-cell transplant (bone marrow transplant). A number of recent studies have contributed to the understanding of HLH pathophysiology, leading to alternate treatment options; however, much work remains to raise awareness and improve the high morbidity and mortality of these complex conditions.
has issue date	2014-06-12(xsd:dateTime)
bibo:doi	10.2147/jbm.s46255
bibo:pmid	24966707
has license	cc-by-nc
sha1sum (hex)	af82e1f7e181393a18fb017ee98abdb17fb78d42
schema:url	https://doi.org/10.2147/jbm.s46255
resource representing a document's title	Hemophagocytic lymphohistiocytosis: review of etiologies and management
has PubMed Central identifier	PMC4062561
has PubMed identifier	24966707
schema:publication	J Blood Med
resource representing a document's body	covid:af82e1f7e181393a18fb017ee98abdb17fb78d42#body_text
is schema:about of	named entity 'BLOOD' named entity 'REVIEW OF' named entity 'ETIOLOGIES' named entity 'high' named entity 'immunosuppression' named entity 'genetic defects' named entity 'immune modulation' named entity 'Blood' named entity 'RELATED' named entity 'CHEMOTHERAPY' named entity 'EARLY RECOGNITION' named entity 'CYTOTOXIC' named entity 'HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS' named entity 'HAVE' named entity 'TRANSPLANT' named entity 'ALTERNATE' named entity 'RECENT' named entity 'VESICLES' named entity 'NATURAL KILLER CELLS' named entity 'FAMILIAL' named entity 'GENETIC' named entity 'CELL TRANSPLANT' named entity 'HLH' named entity 'ATTEMPT' named entity 'IMMUNE MODULATION' named entity 'LEADING' named entity 'MARROW' named entity 'FOLLOWED BY' named entity 'THESE' named entity 'RESULT' named entity 'HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS' named entity 'MEDICINE' named entity 'JOURNAL ' named entity 'MANAGEMENT' named entity 'INTRACELLULAR' named entity 'HIGH' named entity 'TREATMENT OPTIONS' named entity 'COVERS' named entity 'CHARACTERIZED' named entity 'IMMUNOSUPPRESSION' named entity 'MODIFICATION' named entity 'T-CELLS' named entity 'ARRAY' named entity 'AFFECTING' named entity 'ITS' named entity 'LIKELY' named entity 'UNCONTROLLED' named entity 'WORK' named entity 'CONDITIONS' named entity 'PATHOPHYSIOLOGY' named entity 'PERFORIN' named entity 'MUCH' named entity 'AWARENESS' named entity 'WIDE' named entity 'HEMATOPOIETIC' named entity 'CURRENT TREATMENT' named entity 'UNDERSTANDING' named entity 'STEM-CELL' named entity 'INCLUDE' named entity 'INEFFECTIVE' named entity 'REGIMENS' named entity 'RESPONSE' named entity 'IMMUNITY' named entity 'COMPLEX' named entity 'BIOLOGICAL RESPONSE' named entity 'FORMS' named entity 'STUDIES' named entity 'MORBIDITY AND MORTALITY' named entity 'CURATIVE THERAPY' named entity 'LIFE' named entity 'NUMBER OF' named entity 'cytotoxic T-cells' named entity 'therapy' named entity 'morbidity' named entity 'HLH' named entity 'stem-cell transplant' named entity 'Current' named entity 'Hemophagocytic lymphohistiocytosis' named entity 'Journal' named entity 'immunosuppression' named entity 'raise awareness'

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