About: Generalists and Specialists: A New View of How MHC Class I Molecules Fight Infectious Pathogens

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Generalists and Specialists: A New View of How MHC Class I Molecules Fight Infectious Pathogens
Creator	Kaufman, Jim
Source	PMC
abstract	In comparison with the major histocompatibility complexes (MHCs) of typical mammals, the chicken MHC is simple and compact with a single dominantly expressed class I molecule that can determine the immune response. In addition to providing useful information for the poultry industry and allowing insights into the evolution of the adaptive immune system, the simplicity of the chicken MHC has allowed the discovery of phenomena that are more difficult to discern in the more complicated mammalian systems. This review discusses the new concept that poorly expressed promiscuous class I alleles act as generalists to protect against a wide variety of infectious pathogens, while highly expressed fastidious class I alleles can act as specialists to protect against new and dangerous pathogens.
has issue date	2018-05-01(xsd:dateTime)
bibo:doi	10.1016/j.it.2018.01.001
bibo:pmid	29396014
has license	cc-by
sha1sum (hex)	afa40d52e8f5ebf6996e417c9cfeff109b7bb619
schema:url	https://doi.org/10.1016/j.it.2018.01.001
resource representing a document's title	Generalists and Specialists: A New View of How MHC Class I Molecules Fight Infectious Pathogens
has PubMed Central identifier	PMC5929564
has PubMed identifier	29396014
schema:publication	Trends Immunol
resource representing a document's body	covid:afa40d52e8f5ebf6996e417c9cfeff109b7bb619#body_text
is schema:about of	named entity 'IMMUNE RESPONSE' named entity 'SYSTEMS' named entity 'CONCEPT' named entity 'USEFUL INFORMATION' named entity 'DETERMINE' named entity 'PHENOMENA' named entity 'MAMMALIAN' named entity 'MAMMALS' named entity 'ADAPTIVE IMMUNE SYSTEM' named entity 'SPECIALISTS' named entity 'SIMPLE' named entity 'WIDE' named entity 'fastidious' named entity 'PATHOGENS' named entity 'PATHOGENS' named entity 'CLASS I' named entity 'ALLELES' named entity 'COMPLICATED' named entity 'HIGHLY' named entity 'CHICKEN' named entity 'ADDITION' named entity 'MHC' named entity 'ACT' named entity 'EVOLUTION' named entity 'MOLECULE' named entity 'COMPARISON' named entity 'VIEW' named entity 'MOLECULES' named entity 'SPECIALISTS' named entity 'INFECTIOUS' named entity 'MHC CLASS I' named entity 'PROMISCUOUS' named entity 'EXPRESSED' named entity 'POULTRY INDUSTRY' named entity 'DIFFICULT' named entity 'REVIEW' named entity 'MAJOR' named entity 'HISTOCOMPATIBILITY' named entity 'COMPACT' named entity 'NEW' named entity 'HOW' named entity 'FIGHT' named entity 'VARIETY' named entity 'INFECTIOUS' named entity 'PROVIDING' named entity 'ALLOWING' named entity 'NEW' named entity 'POORLY' named entity 'SINGLE' named entity 'INSIGHTS' named entity 'TYPICAL' named entity 'DISCOVERY' named entity 'COMPLEXES' named entity 'mammals' named entity 'MHC' named entity 'discovery' named entity 'alleles' named entity 'insights' named entity 'evolution' named entity 'class I' named entity 'histocompatibility' named entity 'complicated' named entity 'variety' named entity 'generalists' named entity 'highly' named entity 'wide' named entity 'pathogens' named entity 'MHC' named entity 'MHC' named entity 'chicken' named entity 'correlation' named entity 'molecule' named entity 'TAP genes' named entity 'genetic association' named entity 'animal kingdom' named entity 'gene' named entity 'peptides' named entity 'haplotypes' named entity 'tapasin' named entity 'alleles' named entity 'peptide'

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