About: Capacity of serotype 19A and 15B/C Streptococcus pneumoniae isolates for experimental otitis media: implications for the conjugate vaccine

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About: Capacity of serotype 19A and 15B/C Streptococcus pneumoniae isolates for experimental otitis media: implications for the conjugate vaccine Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Capacity of serotype 19A and 15B/C Streptococcus pneumoniae isolates for experimental otitis media: implications for the conjugate vaccine
Creator	Figueira, Marisol Gent, Janneane Pettigrew, Melinda Laufer, Alison Pelton, Stephen Thomas, Jonathan
Source	Elsevier; Medline; PMC
abstract	Non-vaccine Streptococcus pneumoniae serotypes are increasingly associated with disease. We evaluated isolates of the same sequence type (ST199) but different serotype (15B/C, 19A) for growth in vitro, and pathogenic potential in a chinchilla otitis media model. We also developed a qPCR assay to quantitatively assess each isolate, circumventing the need for selectable markers. In vitro studies showed faster growth of serotype 19A over 15B/C. Both were equally capable of colonization and middle ear infection in this model. Serotype 19A is included in new conjugate vaccine formulations while serotype 15B/C is not. Non-capsular vaccine targets will be important in disease prevention efforts.
has issue date	2010-03-01(xsd:dateTime)
bibo:doi	10.1016/j.vaccine.2009.12.078
bibo:pmid	20067753
has license	green-oa
sha1sum (hex)	afc1d001d3a53966f37467dcc2d61ed28c2fdd01
schema:url	https://doi.org/10.1016/j.vaccine.2009.12.078
resource representing a document's title	Capacity of serotype 19A and 15B/C Streptococcus pneumoniae isolates for experimental otitis media: implications for the conjugate vaccine
has PubMed Central identifier	PMC2851619
has PubMed identifier	20067753
schema:publication	Vaccine
resource representing a document's body	covid:afc1d001d3a53966f37467dcc2d61ed28c2fdd01#body_text
is schema:about of	named entity 'pathogenic' named entity 'serotypes' named entity 'conjugate vaccine' named entity 'ISOLATES' named entity 'VACCINE' named entity 'NON-' named entity '19A' named entity 'NEED FOR' named entity 'DIFFERENT' named entity 'INCLUDED' named entity 'CAPSULAR' named entity 'STREPTOCOCCUS PNEUMONIAE' named entity 'CAPACITY' named entity 'ASSAY' named entity 'IN VITRO STUDIES' named entity 'ISOLATE' named entity 'IMPORTANT' named entity '19A' named entity 'EXPERIMENTAL' named entity 'ASSESS' named entity 'DISEASE PREVENTION' named entity 'NEW' named entity 'SEQUENCE TYPE' named entity 'OTITIS MEDIA' named entity 'ISOLATES' named entity 'QUANTITATIVE PCR' named entity 'SELECTABLE MARKERS' named entity 'CONJUGATE VACCINE' named entity 'COLONIZATION' named entity 'EVALUATED' named entity 'FASTER GROWTH' named entity 'SEROTYPES' named entity 'BUT' named entity 'POTENTIAL' named entity 'MIDDLE EAR INFECTION' named entity 'IN VITRO' named entity 'TARGETS' named entity 'MODEL' named entity 'CAPABLE' named entity 'CONJUGATE VACCINE' named entity 'OTITIS MEDIA' named entity 'DISEASE' named entity 'PATHOGENIC' named entity 'ASSOCIATED WITH' named entity 'CHINCHILLA' named entity 'SEROTYPE' named entity 'STREPTOCOCCUS PNEUMONIAE' named entity 'GROWTH' named entity 'SEROTYPE' covid:arg/afc1d001d3a53966f37467dcc2d61ed28c2fdd01 named entity 'assay' named entity 'faster' named entity 'sequence' named entity 'serotype' named entity 'Wyeth' named entity 'Serotype' named entity 'middle ear' named entity 'serotype' named entity 'colonization' named entity 'Serotype' named entity 'qPCR' named entity '15B' named entity 'serotype' named entity 'serotypes' named entity 'disease prevention' named entity 'Streptococcus pneumoniae' named entity 'serotype' named entity 'qPCR' named entity 'PCR amplification' named entity 'virulent' named entity 'serotypes' named entity 'sepsis' named entity 'phosphotransferase' named entity 'plasmid' named entity 'tympanometry' named entity 'bacteremic pneumonia'

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