About: Early-life respiratory viral infections, atopic sensitization, and risk of subsequent development of persistent asthma

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About: Early-life respiratory viral infections, atopic sensitization, and risk of subsequent development of persistent asthma Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Early-life respiratory viral infections, atopic sensitization, and risk of subsequent development of persistent asthma
Creator	Kusel, Merci Johnston, Sebastian Kebadze, Tatiana Holt, Patrick Sly, Peter Australia, London De Klerk, Nicholas Perth, Vohma, Vaike
Source	Elsevier; Medline; PMC
abstract	Background Severe lower respiratory infections (LRIs) and atopic sensitization have been identified as independent risk factors for asthma. Objective The nature of potential interactions between these risk factors was the subject of this study. Methods A community-based cohort of 198 children at high atopic risk was followed from birth to 5 years. All episodes of acute respiratory illness in the first year were recorded and postnasal aspirates were collected for viral identification. History of wheeze and asthma was collected annually, and atopy was assessed at 6 months, 2 years, and 5 years. Results A total of 815 episodes of acute respiratory illness were reported, and 33% were LRIs. Viruses were detected in 69% of aspirates, most commonly rhinoviruses (48.3%) and respiratory syncytial virus (10.9%). At 5 years, 28.3%(n = 56) had current wheeze, and this was associated with wheezy [odds ratio (OR), 3.4 (1.2-9.7); P = .02] and/or febrile LRI [OR, 3.9 (1.4-10.5); P = .007], in particular those caused by respiratory syncytial virus or rhinoviruses [OR, 4.1 (1.3-12.6); P = .02]. Comparable findings were made for current asthma. Strikingly these associations were restricted to children who displayed early sensitization (≤2 years old) and not observed in nonatopic patients or those sensitized later. Conclusion These data suggest viral infections interact with atopy in infancy to promote later asthma. Notably the occurrence of both of these events during this narrow developmental window is associated with maximal risk for subsequent asthma, which suggests a contribution from both classes of inflammatory insults to disease pathogenesis. Clinical implications Protection of “high-risk” children against the effects of severe respiratory infections during infancy may represent an effective strategy for primary asthma prevention. The potential benefits of these strategies merit more careful evaluation in this age group.
has issue date	2007-05-31(xsd:dateTime)
bibo:doi	10.1016/j.jaci.2006.12.669
bibo:pmid	17353039
has license	els-covid
sha1sum (hex)	afe8566ab2726a0c5c0801739999194e90294a16
schema:url	https://doi.org/10.1016/j.jaci.2006.12.669
resource representing a document's title	Early-life respiratory viral infections, atopic sensitization, and risk of subsequent development of persistent asthma
has PubMed Central identifier	PMC7125611
has PubMed identifier	17353039
schema:publication	Journal of Allergy and Clinical Immunology
resource representing a document's body	covid:afe8566ab2726a0c5c0801739999194e90294a16#body_text
is schema:about of	named entity 'development' named entity 'PERSISTENT ASTHMA' named entity 'LIFE' named entity 'RESPIRATORY' named entity 'ATOPIC' named entity 'EARLY' named entity 'SENSITIZATION' named entity 'VIRAL INFECTIONS' named entity 'DEVELOPMENT' named entity 'SUBSEQUENT' named entity 'RISK OF' named entity 'respiratory infections' named entity 'wheeze' named entity 'asthma' named entity 'asthma' named entity 'SPSS' named entity 'etiology' named entity 'asthma' named entity 'RSV' named entity 'wheeze' named entity 'wheezing' named entity 'rhinovirus' named entity 'window period' named entity 'respiratory illness' named entity 'wheezing' named entity 'Wheeze' named entity 'viral infection' named entity 'wheeze' named entity 'wheeze' named entity 'rhinovirus' named entity 'statistical support' named entity 'wheezing' named entity 'rhinovirus' named entity 'antiviral' named entity 'wheezing' named entity 'atopy' named entity 'long-term' named entity '11.6' named entity 'viral infection' named entity 'wheeze' named entity 'rhinovirus' named entity '95% CI' named entity 'wheeze' named entity 'wheezing' named entity 'study population' named entity 'cough' named entity 'tachypnoea' named entity 'Tucson' named entity 'wheezing' named entity 'immune mechanisms' named entity 'asthma' named entity 'persistent' named entity 'atopic sensitization' named entity 'parainfluenza' named entity 'wheeze' named entity 'respiratory symptoms' named entity 'house dust mite' named entity 'etiology' named entity 'RSV' named entity 'disease processes' named entity 'synergistically' named entity 'tissue differentiation' named entity 'cough' named entity 'asthma' named entity 'anti-inflammatory drugs' named entity 'asthma' named entity 'follow-up' named entity '95% CI' named entity 'rhinovirus' named entity 'asthma' named entity 'respiratory syncytial virus' named entity 'inhaled corticosteroids' named entity 'RSV'

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