About: Detection of viral, Chlamydia pneumoniae and Mycoplasma pneumoniae infections in exacerbations of asthma in children

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About: Detection of viral, Chlamydia pneumoniae and Mycoplasma pneumoniae infections in exacerbations of asthma in children Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Detection of viral, Chlamydia pneumoniae and Mycoplasma pneumoniae infections in exacerbations of asthma in children
Creator	Brouard, Jacques Duhamel, Jean-François Freymuth, François Gouarin, Stéphanie Guillois, Bernard Vabret, Astrid Petitjean, Joelle Toutain, Fabienne Verdon, Renaud
source	Elsevier; Medline; PMC
abstract	Abstract Background: A high frequency of virus infections has been recently pointed out in the exacerbations of asthma in children. Objectives: To confirm this, using conventional and molecular detection methods, and expanding the study to younger children. Study design: One hundred and thirty-two nasal aspirates from 75 children hospitalized for a severe attack of asthma were studied (32 infants, mean age 9.1 months; and 43 children, mean age 5.6 years). According to the virus, a viral isolation technique, immunofluorescence assays (IFA) or both were used for the detection of rhinovirus, enterovirus, respiratory syncytial (RS) virus, adenovirus, coronavirus 229E, influenza and parainfluenza virus. Polymerase chain reaction (PCR) assays were used for the detection of rhinovirus, enterovirus, RS virus, adenovirus, coronavirus 229E and OC43, Chlamydia pneumoniae and Mycoplasma pneumoniae. Results: Using IFA and viral isolation techniques, viruses were detected in 33.3% of cases, and by PCR techniques, nucleic acid sequences of virus, Chlamydia pneumoniae and Mycoplasma pneumoniae were obtained in 71.9% of cases. The combination of conventional and molecular techniques detects 81.8% of positive samples. Two organisms were identified in the same nasal sample in 20.4% of the cases. The percentage of detections was higher (85.9%) in the younger group than in the other (77%). The most frequently detected agents were rhinovirus (46.9%) and RS virus (21.2%). Using PCR rather than conventional techniques, the detection rates were increased 5.8- and 1.6-fold in rhinovirus and RS virus infections, respectively. The detection levels of the other organisms are as follows: 9.8, 5.1, 4.5, 4.5, 4.5, 3.7, and 2.2% for enterovirus, influenza virus, Chlamydia pneumoniae, adenovirus, coronavirus, parainfluenza virus, and Mycoplasma pneumoniae, respectively. Conclusion: These results confirm the previously reported high frequency of rhinovirus detection in asthmatic exacerbations in children. They also point out the frequency of RS virus detection, and emphasize the fact that PCR assays may be necessary to diagnose respiratory infections in asthma.
has issue date	1999-08-31(xsd:dateTime)
bibo:doi	10.1016/s1386-6532(99)00030-x
bibo:pmid	10443789
has license	els-covid
sha1sum (hex)	afe93f0f61df66fce765a48ed5af093074d3b23e
schema:url	https://doi.org/10.1016/s1386-6532%2899%2900030-x
resource representing a document's title	Detection of viral, Chlamydia pneumoniae and Mycoplasma pneumoniae infections in exacerbations of asthma in children
has PubMed Central identifier	PMC7129880
has PubMed identifier	10443789
schema:publication	Journal of Clinical Virology
resource representing a document's body	covid:afe93f0f61df66fce765a48ed5af093074d3b23e#body_text
is schema:about of	named entity 'Detection' named entity 'Chlamydia pneumoniae' named entity 'VIRAL' named entity 'INFECTIONS' named entity 'CONVENTIONAL' named entity 'YOUNGER' covid:arg/afe93f0f61df66fce765a48ed5af093074d3b23e named entity 'MYCOPLASMA PNEUMONIAE' named entity 'CHILDREN' named entity 'OBJECTIVES' named entity 'MOLECULAR' named entity 'USING' named entity 'DETECTION METHODS' named entity 'ASTHMA IN CHILDREN' named entity 'CHLAMYDIA PNEUMONIAE' named entity 'STUDY' named entity 'DETECTION' named entity 'CONFIRM' named entity 'EXPANDING' named entity 'rhinovirus' named entity '2.2' named entity 'viral infections' named entity 'pathogen' named entity 'Molecular techniques' named entity 'viruses' named entity 'asthma' named entity 'Mycoplasma pneumoniae' named entity 'primers' named entity 'coronavirus' named entity 'adenovirus' named entity 'France' named entity 'bronchiolitis' named entity 'influenza virus' named entity '229E' named entity 'influenza virus' named entity 'adenovirus' named entity 'PCR' named entity 'parainfluenza virus' named entity 'rhinovirus' named entity 'serology' named entity 'PCR' named entity 'infectious agents' named entity 'parainfluenza virus' named entity 'Chlamydia pneumoniae' named entity 'Mycoplasma pneumoniae' named entity 'inoculation' named entity 'OC43' named entity 'adenovirus' named entity 'rhinovirus' named entity 'monoclonal antibodies' named entity 'PCR amplification' named entity 'Mycoplasma pneumoniae' named entity 'acute respiratory illnesses' named entity 'OC43' named entity 'RT-PCR' named entity 'viruses' named entity 'Mycoplasma pneumoniae' named entity 'rhinovirus' named entity '2.1' named entity 'upper respiratory tract' named entity 'influenza virus' named entity '5.6' named entity 'coronavirus' named entity 'electrophoresis' named entity 'coronavirus infections' named entity 'enterovirus' named entity 'Mycoplasma pneumoniae' named entity 'asthma' named entity 'Chlamydia pneumoniae' named entity 'Mycoplasma pneumoniae' named entity 'asthma' named entity 'immunoglobulin' named entity 'enterovirus'

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