Novaferon inhibited the viral replication ( EC50 = 1 . 02 ng / ml ) , and prevented viral infection ( EC50 = 0 . 10 ng / ml ) . Results from the 89 enrolled COVID - 19 patients showed that both Novaferon and Novaferon plus Lopinavir / Ritonavir groups had significantly higher viral clearance rates on day 6than Lopinavir