The results show that CXCL10 ( −938AA ) is always protective whenever it appears , but appears rarely and only jointly with either Fgl2 ( + 158T / * ) or HO - 1 ( −497A / * ) , while ( Fgl2 ) ( + 158T / * ) is associated with higher susceptibility unless combined with CXCL10 / IP - 10 ( −