About: SARS-CoV-2 targets cortical neurons of 3D human brain organoids and shows neurodegeneration-like effects

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About: SARS-CoV-2 targets cortical neurons of 3D human brain organoids and shows neurodegeneration-like effects Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	SARS-CoV-2 targets cortical neurons of 3D human brain organoids and shows neurodegeneration-like effects
Creator	Adams, Ortwin Omran, Heymut Schaal, Heiner Wieczorek, Dagmar Timm, Jörg Andrée, Marcel Gruell, Henning Hauka, Sandra Klein, Florian Walker, Andreas Dilthey, Alexander Houwaart, Torsten Abida-Islam, Pranty Gabriel, Elke Gopalakrishnan, Jay Goureau, Olivier Korth, Carsten Mariappan, Aruljothi Müller, Lisa Müller-Schiffmann, Andreas Niklas, Philipp Wohlgemuth, Kai
Source	BioRxiv
abstract	COVID-19 pandemic caused by SARS-CoV-2 infection is a public health emergency. COVID-19 typically exhibits respiratory illness. Unexpectedly, emerging clinical reports indicate that neurological symptoms continue to rise, suggesting detrimental effects of SARS-CoV-2 on the central nervous system (CNS). Here, we show that a Düsseldorf isolate of SARS-CoV-2 enters 3D human brain organoids within two days of exposure. Using COVID-19 convalescent serum, we identified that SARS-CoV-2 preferably targets soma of cortical neurons but not neural stem cells, the target cell type of ZIKA virus. Imaging cortical neurons of organoids reveal that SARS-CoV-2 exposure is associated with missorted Tau from axons to soma, hyperphosphorylation, and apparent neuronal death. Surprisingly, SARS-CoV-2 co-localizes specifically with Tau phosphorylated at Threonine-231 in the soma, indicative of early neurodegeneration-like effects. Our studies, therefore, provide initial insights into the impact of SARS-CoV-2 as a neurotropic virus and emphasize that brain organoids could model CNS pathologies of COVID-19. One sentence summary COVID-19 modeling in human brain organoids
has issue date	2020-05-20(xsd:dateTime)
bibo:doi	10.1101/2020.05.20.106575
has license	biorxiv
sha1sum (hex)	b01b752eb569195877576fa12d80202d7b713d90
schema:url	https://doi.org/10.1101/2020.05.20.106575
resource representing a document's title	SARS-CoV-2 targets cortical neurons of 3D human brain organoids and shows neurodegeneration-like effects
schema:publication	bioRxiv
resource representing a document's body	covid:b01b752eb569195877576fa12d80202d7b713d90#body_text
is schema:about of	named entity 'brain' named entity 'neurons' named entity 'effects' named entity 'iPSCs' named entity 'Vero cells' named entity 'spike protein' named entity 'neural progenitors' named entity 'CO2' named entity 'Severe Acute Respiratory Syndrome Coronavirus 2' named entity 'cell death' named entity 'DAPI' named entity 'SARS-CoV-2' named entity 'epithelia' named entity 'neurons' named entity 'Vancouver' named entity 'inoculation' named entity 'Sodium citrate' named entity 'Tauopathies' named entity 'infection' named entity 'CNS' named entity 'SARS-CoV' named entity 'Fetal Calf Serum' named entity 'virus' named entity 'bioengineered' named entity 'SARS-CoV-2' named entity 'organoids' named entity 'soma' named entity 'organoid' named entity 'neuronal stress' named entity 'infection' named entity 'kidney' named entity 'CNS' named entity 'SARS' named entity 'AB4' named entity 'Streptomycin' named entity 'convalescent serum' named entity 'supernatant' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'nucleoprotein' named entity 'staining' named entity 'neural stem cells' named entity 'cell death' named entity 'SARS-CoV-2' named entity 'Cortical neurons' named entity 'human brain' named entity 'Cryostat' named entity 'Germany' named entity 'Sigma Aldrich' named entity 'transgenic mice' named entity 'cortical area' named entity 'traumatic brain injury' named entity 'Canada' named entity 'RPMI' named entity 'serum' named entity 'neurological symptoms' named entity 'SARS-CoV-2' named entity 'virus entry' named entity 'SARS-CoV-2' named entity 'TUNEL' named entity 'respiratory tract' named entity 'COVID' named entity 'cortical neurons'

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