About: Genetic variants in TMPRSS2 and Structure of SARS-CoV-2 spike glycoprotein and TMPRSS2 complex

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About: Genetic variants in TMPRSS2 and Structure of SARS-CoV-2 spike glycoprotein and TMPRSS2 complex Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Genetic variants in TMPRSS2 and Structure of SARS-CoV-2 spike glycoprotein and TMPRSS2 complex
Creator	Vankadari, Naveen Amanchy, Ramars Avanthi, Steffie Govardhan Bale, Ketavarapu, Vijayasarathy Reddy, Duvvur Sasikala, Mitnala Vishnubhotla, Ravikanth
Source	BioRxiv
abstract	SARS-CoV-2, a highly transmittable pathogen has infected over 3.8 million people around the globe. The spike glycoprotein of SARS-CoV-2 engages host ACE2 for adhesion, TMPRSS2 for activation and entry. With the aid of whole-exome sequencing, we report a variant rs12329760 in TMPRSS2 gene and its mutant V160M, which might impede viral entry. Furthermore, we identified TMPRSS2 cleavage sites in S2 domain of spike glycoprotein and report the structure of TMPRSS2 in complex with spike glycoprotein. We also report the structures of protease inhibitors in complex with TMPRSS2, which could hamper the interaction with spike protein. These findings advance our understanding on the role of TMPRSS2 and in the development of potential therapeutics.
has issue date	2020-06-30(xsd:dateTime)
bibo:doi	10.1101/2020.06.30.179663
has license	biorxiv
sha1sum (hex)	b02278659852b7a9b72891eb9a86e2673f93ee7d
schema:url	https://doi.org/10.1101/2020.06.30.179663
resource representing a document's title	Genetic variants in TMPRSS2 and Structure of SARS-CoV-2 spike glycoprotein and TMPRSS2 complex
schema:publication	bioRxiv
resource representing a document's body	covid:b02278659852b7a9b72891eb9a86e2673f93ee7d#body_text
is schema:about of	named entity 'infected' named entity 'spike' named entity 'SARS-CoV-2' named entity 'adhesion' named entity 'highly' named entity 'globe' named entity 'SARS-CoV-2' named entity 'TMPRSS2' named entity 'TMPRSS2' named entity '7.5' named entity 'SARS-CoV-2' named entity 'C-Score' named entity 'region1' named entity 'ACE2' named entity 'glycoprotein' named entity 'TMPRSS2' named entity 'virulence' named entity 'ultrasound' named entity 'CCP4' named entity 'TMPRSS2' named entity 'exome' named entity 'Nafamostat' named entity 'COVID' named entity 'TMPRSS2' named entity 'glycoprotein' named entity 'epidemiological' named entity 'TMPRSS2' named entity 'mortality rates' named entity 'Molecular docking' named entity 'viral strain' named entity 'Valine' named entity 'sequenced' named entity 'protein' named entity 'protein' named entity 'glycoprotein' named entity 'PyMol' named entity 'protein' named entity 'catalytic site' named entity 'TMPRSS2' named entity 'TMPRSS2' named entity 'proteolytic' named entity 'TMPRSS2' named entity 'genetic predisposition' named entity 'TMPRSS2' named entity 'HR2' named entity 'genetic variant' named entity 'TMPRSS2' named entity 'SARS-CoV-2' named entity 'COVID-19 infection' named entity 'Z-score' named entity 'BMI' named entity 'TMPRSS2' named entity 'spike protein' named entity 'TMPRSS2' named entity 'TMPRSS2' named entity 'glycoprotein' named entity 'host cells' named entity 'TMPRSS2' named entity 'TMPRSS2' named entity 'PDB' named entity 'serine protease' named entity 'scavenger receptor' named entity 'glycoprotein' named entity 'general population' named entity 'spike protein' named entity 'Exome sequencing' named entity 'free energy' named entity 'human genome' named entity 'furin' named entity 'TMPRSS2' named entity 'sequence analysis' named entity 'molecular docking' named entity 'SIFT' named entity 'SARS-CoV-2' named entity 'minor allele frequency' named entity 'infectivity' named entity 'serine protease inhibitor'

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