About: Depletion of angiotensin-converting enzyme 2 reduces brain serotonin and impairs the running-induced neurogenic response

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About: Depletion of angiotensin-converting enzyme 2 reduces brain serotonin and impairs the running-induced neurogenic response Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Depletion of angiotensin-converting enzyme 2 reduces brain serotonin and impairs the running-induced neurogenic response
Creator	Alenina, Natalia Penninger, Josef Todiras, Mihail Klempin, Friederike Matthes, Susann Mosienko, Valentina Bader, · Daniel, · Robson, · Santos, A Villela, C
Source	Medline; PMC
abstract	Physical exercise induces cell proliferation in the adult hippocampus in rodents. Serotonin (5-HT) and angiotensin (Ang) II are important mediators of the pro-mitotic effect of physical activity. Here, we examine precursor cells in the adult brain of mice lacking angiotensin-converting enzyme (ACE) 2, and explore the effect of an acute running stimulus on neurogenesis. ACE2 metabolizes Ang II to Ang-(1–7) and is essential for the intestinal uptake of tryptophan (Trp), the 5-HT precursor. In ACE2-deficient mice, we observed a decrease in brain 5-HT levels and no increase in the number of BrdU-positive cells following exercise. Targeting the Ang II/AT1 axis by blocking the receptor, or experimentally increasing Trp/5-HT levels in the brain of ACE2-deficient mice, did not rescue the running-induced effect. Furthermore, mice lacking the Ang-(1–7) receptor, Mas, presented a normal neurogenic response to exercise. Our results identify ACE2 as a novel factor required for exercise-dependent modulation of adult neurogenesis and essential for 5-HT metabolism.
has issue date	2018-04-20(xsd:dateTime)
bibo:doi	10.1007/s00018-018-2815-y
bibo:pmid	29679094
has license	no-cc
sha1sum (hex)	b038d6e7a5b83503beed67bb588748319e50efa6
schema:url	https://doi.org/10.1007/s00018-018-2815-y
resource representing a document's title	Depletion of angiotensin-converting enzyme 2 reduces brain serotonin and impairs the running-induced neurogenic response
has PubMed Central identifier	PMC7079801
has PubMed identifier	29679094
schema:publication	Cell Mol Life Sci
resource representing a document's body	covid:b038d6e7a5b83503beed67bb588748319e50efa6#body_text
is schema:about of	named entity 'modulation' named entity 'brain' named entity 'Trp' named entity 'response' named entity 'RESPONSE' named entity 'SEROTONIN' named entity 'NUMBER OF' named entity 'MODULATION' named entity 'RECEPTOR' named entity 'SEROTONIN' named entity 'INTESTINAL' named entity 'TARGETING' named entity 'REQUIRED' named entity 'POSITIVE' named entity 'METABOLISM' named entity 'ACE2' named entity 'ACUTE' named entity 'FACTOR' named entity 'CELLS' named entity 'PRECURSOR CELLS' named entity 'MICE' named entity 'INDUCED' named entity 'ESSENTIAL' named entity '5-HT' named entity 'BRDU' named entity 'PHYSICAL EXERCISE' named entity 'FOLLOWING EXERCISE' named entity 'ANGIOTENSIN-CONVERTING ENZYME 2' named entity 'DEPLETION' named entity 'NEUROGENIC' named entity 'NEUROGENESIS' named entity 'RODENTS' named entity 'BRAIN' named entity 'IMPAIRS' named entity 'RUNNING' named entity 'NEUROGENIC' named entity 'PRESENTED' named entity 'NORMAL' named entity 'TRYPTOPHAN' named entity 'LEVELS' named entity 'IDENTIFY' named entity 'ADULT' named entity 'MITOTIC' named entity 'ANGIOTENSIN' named entity 'RUNNING' named entity 'INCREASE' named entity 'TRP' named entity 'BLOCKING' named entity 'RESPONSE TO EXERCISE' named entity 'PHYSICAL ACTIVITY' named entity 'EXERCISE' named entity 'OUR' named entity 'DEFICIENT' named entity 'NOVEL' named entity 'OBSERVED' named entity 'PRO-' named entity 'HIPPOCAMPUS' named entity 'MAS' named entity 'HERE' named entity 'ANG II' named entity 'EFFECT' named entity 'DEPENDENT' named entity 'DID' named entity 'CELL PROLIFERATION' named entity 'PRECURSOR' named entity 'ADULT BRAIN' named entity 'ANG' named entity 'BRAIN' named entity 'MEDIATORS' named entity 'IMPORTANT' named entity 'ANGIOTENSIN-CONVERTING ENZYME'

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