About: RETRACTED: Autoadaptive ER-Associated Degradation Defines a Preemptive Unfolded Protein Response Pathway

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About: RETRACTED: Autoadaptive ER-Associated Degradation Defines a Preemptive Unfolded Protein Response Pathway Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	RETRACTED: Autoadaptive ER-Associated Degradation Defines a Preemptive Unfolded Protein Response Pathway
Creator	Bernasconi, Riccardo Galli, Carmela Molinari, Maurizio Kokame, Koichi
Source	Elsevier; Medline
abstract	This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the authors. The study reported that expression of misfolded proteins in the ER affects the composition and stability of the dislocation machinery built around the HRD1 E3 ubiquitin ligase in the absence of UPR induction. During efforts to extend this work, the authors have been unable to replicate some of the results obtained by the first author of the paper, which describe the mechanisms regulating the rapid turnover of HERP and how the presence of misfolded proteins affects the composition and the stability of the HRD1 complex. The authors therefore wish to immediately retract the paper. The authors’ lab continues working on the regulation of the ERAD machinery aiming to publish verified data in t52/6he near future. The authors sincerely apologize for any difficulties that may have been experienced by the scientific community. The first author, R.B., declined to sign the retraction notice.
has issue date	2013-12-26(xsd:dateTime)
bibo:doi	10.1016/j.molcel.2013.10.016
bibo:pmid	24239290
has license	els-covid
sha1sum (hex)	b0407f35d4c09d63357ff8a5d89e274bbbdbba0c
schema:url	https://doi.org/10.1016/j.molcel.2013.10.016
resource representing a document's title	RETRACTED: Autoadaptive ER-Associated Degradation Defines a Preemptive Unfolded Protein Response Pathway
has PubMed identifier	24239290
schema:publication	Molecular Cell
resource representing a document's body	covid:b0407f35d4c09d63357ff8a5d89e274bbbdbba0c#body_text
is schema:about of	named entity 'DEGRADATION' named entity 'cleared' named entity 'interrupt' named entity 'ERAD' named entity 'folding' named entity 'degradation' named entity 'integrity' named entity 'turnover' named entity 'ER-' named entity 'UNFOLDED PROTEIN RESPONSE' named entity 'PRESENCE OF' named entity 'DISLOCATION' named entity 'CONTROLLED' named entity 'ER MEMBRANE' named entity 'INSTABILITY' named entity 'ADAPT' named entity 'MISFOLDED' named entity 'FOLDING' named entity 'PROTEOSTASIS' named entity 'PATHWAYS' named entity 'PROTEIN ' named entity 'TO PREVENT' named entity 'RAPID' named entity 'INTEGRITY' named entity 'UBC6E' named entity 'TURNOVER' named entity 'PERTURBATION' named entity 'ACTIVITY' named entity 'THEIR' named entity 'PROMOTE' named entity 'ENDOPLASMIC RETICULUM' named entity 'TO MAINTAIN' named entity 'ER-' named entity 'UNFOLDED PROTEIN RESPONSE' named entity 'HERE' named entity 'INTERRUPT' named entity 'RAPIDLY' named entity 'HRD1' named entity 'ARTICLE' named entity 'ASSOCIATED' named entity 'CELLULAR' named entity 'SCAFFOLD PROTEIN' named entity 'DOSE-DEPENDENT' named entity 'UBIQUITIN LIGASES' named entity 'PATHWAY' named entity 'RELAY' named entity 'DEFINED' named entity 'INTRINSIC' named entity 'TRANSPORT' named entity 'ACROSS' named entity 'REGULATORY' named entity 'REPORT' named entity 'ENGAGE' named entity 'ENVIRONMENT' named entity 'PROTEINS' named entity 'PROTEASOMAL DEGRADATION' named entity 'ACTIVATION' named entity 'PREEMPT' named entity 'HERP' named entity 'LOAD' named entity 'DEFECTIVE' named entity 'ERAD' named entity 'CLEARED' named entity 'PROTEASOME' named entity 'CLIENTS' named entity 'DEGRADATION' named entity 'ASSOCIATED' named entity 'prevent' named entity 'cellular' named entity 'clients' named entity 'instability' named entity 'HRD1' named entity 'dose-dependent manner' named entity 'ER-associated degradation' named entity 'proteasome' named entity 'proteostasis' named entity 'HERP' named entity 'RNA' named entity 'HeLa'

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