About: Lethal Respiratory Disease Associated with Human Rhinovirus C in Wild Chimpanzees, Uganda, 2013

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About: Lethal Respiratory Disease Associated with Human Rhinovirus C in Wild Chimpanzees, Uganda, 2013 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Lethal Respiratory Disease Associated with Human Rhinovirus C in Wild Chimpanzees, Uganda, 2013
Creator	Pappas, Tressa Hyeroba, David Machanda, Zarin Otali, Emily Gern, James Grindle, Kristine Madison, Goldberg, Tony Palmenberg, Ann Muller, Martin Scully, Erik Wrangham, Richard Thompson, Melissa Basnet, K Basnet, Sarmi Gern, T Grindle, T Madison, S Palmenberg, J Pappas, K Watters, A Watters, Kelly
source	Medline; PMC
abstract	We describe a lethal respiratory outbreak among wild chimpanzees in Uganda in 2013 for which molecular and epidemiologic analyses implicate human rhinovirus C as the cause. Postmortem samples from an infant chimpanzee yielded near-complete genome sequences throughout the respiratory tract; other pathogens were absent. Epidemiologic modeling estimated the basic reproductive number (R(0)) for the epidemic as 1.83, consistent with the common cold in humans. Genotyping of 41 chimpanzees and examination of 24 published chimpanzee genomes from subspecies across Africa showed universal homozygosity for the cadherin-related family member 3 CDHR3-Y(529) allele, which increases risk for rhinovirus C infection and asthma in human children. These results indicate that chimpanzees exhibit a species-wide genetic susceptibility to rhinovirus C and that this virus, heretofore considered a uniquely human pathogen, can cross primate species barriers and threatens wild apes. We advocate engineering interventions and prevention strategies for rhinovirus infections for both humans and wild apes.
has issue date	2018-02-01(xsd:dateTime)
bibo:doi	10.3201/eid2402.170778
bibo:pmid	29350142
has license	no-cc
sha1sum (hex)	b08606b5f6be82d6677b7375799f5a3c2a1d2f0b
schema:url	https://doi.org/10.3201/eid2402.170778
resource representing a document's title	Lethal Respiratory Disease Associated with Human Rhinovirus C in Wild Chimpanzees, Uganda, 2013
has PubMed Central identifier	PMC5782908
has PubMed identifier	29350142
schema:publication	Emerg Infect Dis
resource representing a document's body	covid:b08606b5f6be82d6677b7375799f5a3c2a1d2f0b#body_text
is schema:about of	named entity 'Uganda' named entity 'chimpanzees' named entity 'feces' named entity 'respiratory disease' named entity 'Thermo Fisher' named entity 'homogenized' named entity 'rhinovirus' named entity 'epidemic' named entity 'wild relatives' named entity 'best-fit' named entity 'rhinovirus' named entity 'Dacron' named entity 'cDNA' named entity 'MS2' named entity 'rhinovirus' named entity 'genotypes' named entity 'Thermo Fisher' named entity 'transmission rate' named entity 'National Research Council' named entity 'polyprotein' named entity 'CDHR3' named entity 'clinical samples' named entity 'virus' named entity 'United States' named entity 'chimpanzee' named entity 'coughing' named entity 'rhinovirus' named entity 'pathogens' named entity 'allele' named entity 'Chlamydophila pneumoniae' named entity 'chimpanzee' named entity 'allelic' named entity 'chimpanzees' named entity 'adenoviruses' named entity 'epidemic' named entity 'pathogen' named entity 'lung' named entity 'recombination' named entity 'simian immunodeficiency virus' named entity 'veterinarian' named entity 'rhinovirus' named entity 'chimpanzees' named entity 'amino acid' named entity 'subspecies' named entity 'positive swab' named entity 'genotyped' named entity 'pathogens' named entity 'Assay' named entity 'genome sequences' named entity 'rhinovirus' named entity 'Luminex' named entity 'epidemiologic' named entity 'hygiene' named entity 'genomes' named entity 'chimpanzees' named entity 'epidemiologic' named entity 'statistical confidence' named entity 'heterogeneity' named entity 'GenBank' named entity 'genomic variants'

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