About: Complete genome comparison of porcine reproductive and respiratory syndrome virus parental and attenuated strains

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Complete genome comparison of porcine reproductive and respiratory syndrome virus parental and attenuated strains
Creator	Yuan, Shishan Murtaugh, Michael Mickelson, Daniel Faaberg, Kay
Source	Elsevier; Medline; PMC
abstract	Abstract Two full-length porcine reproductive and respiratory syndrome virus (PRRSV) genomes, strain VR-2332 and its cell culture passaged descendent RespPRRS vaccine strain, were compared and analyzed in order to identify possible sites of attenuation. Of the 44 nucleotide changes, 13 resulted in conservative changes and 18 produced non-conservative changes. The results suggest that key amino acids in ORF1 may contribute to the phenotype of RespPRRS, which includes increased growth rate on MA-104 cells and decreased virulence in swine. The results provide a genetic basis for future manipulation of a PRRSV reverse genetics system.
has issue date	2001-04-30(xsd:dateTime)
bibo:doi	10.1016/s0168-1702(00)00250-1
bibo:pmid	11226578
has license	els-covid
sha1sum (hex)	b0928ad2dfc5b060fc16da953260b321b0184994
schema:url	https://doi.org/10.1016/s0168-1702%2800%2900250-1
resource representing a document's title	Complete genome comparison of porcine reproductive and respiratory syndrome virus parental and attenuated strains
has PubMed Central identifier	PMC7125765
has PubMed identifier	11226578
schema:publication	Virus Research
resource representing a document's body	covid:b0928ad2dfc5b060fc16da953260b321b0184994#body_text
is schema:about of	named entity 'STRAINS' named entity 'GENOME COMPARISON' named entity 'phenotype' named entity 'produced' named entity 'cell culture' named entity 'LENGTH' named entity 'ANALYZED' named entity 'NON-' named entity 'MANIPULATION' named entity 'COMPARED' named entity 'CONTRIBUTE ' named entity 'STRAIN' named entity 'SWINE' named entity 'PROVIDE' named entity 'ORDER' named entity 'FUTURE' named entity 'KEY' named entity 'PHENOTYPE' named entity 'SITES' named entity 'PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS' named entity 'PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS' named entity '104' named entity 'VACCINE STRAIN' named entity 'REVERSE GENETICS' named entity 'POSSIBLE' named entity 'INCLUDES' covid:arg/b0928ad2dfc5b060fc16da953260b321b0184994 named entity 'BASIS' named entity 'ATTENUATION' named entity 'RESULTS' named entity 'AMINO ACIDS' named entity 'TO IDENTIFY' named entity 'COMPLETE' named entity 'PARENTAL' named entity 'DECREASED VIRULENCE' named entity 'CELLS' named entity 'CHANGES' named entity 'ITS' named entity 'INCREASED GROWTH RATE' named entity 'SUGGEST' named entity 'NUCLEOTIDE' named entity 'CELL CULTURE' named entity 'GENOMES' named entity 'SYSTEM' named entity 'GENETIC' named entity 'ORF1' named entity 'DESCENDENT' named entity 'ATTENUATED' named entity 'reverse genetics' named entity 'manipulation' named entity 'order' named entity 'virulence' named entity 'Two' named entity 'strain' named entity 'porcine' named entity 'nucleotide' named entity 'genomes' named entity 'attenuation' named entity 'ORF1' named entity 'swine' named entity 'PRRSV' named entity 'genome' named entity 'nucleotide' named entity 'viral strain' named entity 'signal sequence' named entity 'mutation' named entity 'centrifuged' named entity 'nucleotide sequence' named entity 'proteases' named entity 'virus' named entity 'optical density' named entity 'genome' named entity 'supernatants' named entity 'PRRSV' named entity 'New England Biolabs' named entity 'virion' named entity 'amino acid' named entity 'protein domains'

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