About: Clinical features, complications and atypical manifestations of children with severe forms of dengue hemorrhagic fever in South India

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About: Clinical features, complications and atypical manifestations of children with severe forms of dengue hemorrhagic fever in South India Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Clinical features, complications and atypical manifestations of children with severe forms of dengue hemorrhagic fever in South India
Creator	Kamath, Shrishu Ranjit, Suchitra
Source	PMC
abstract	OBJECTIVE: To review clinical features and outcome of children with severe forms of dengue hemorrhagic fever (DHF) presenting to a pediatric intensive care unit (PICU) with particular focus on clinical presentation and outcome. METHODS: Retrospective chart review of patients admitted to the Pediatric Intensive Care Unit (PICU) of a referral children's hospital in South India with DHF over 1.5 years (2001–January 2003). RESULTS: Of 858 patients with dengue fever/DHF admitted to the hospital during the study period, 109 cases with severe forms of disease required PICU admission, of which 9 patients died. 77 were under 5 years of age. The commonest indication for PICU admission was persistent shock (39 patients) followed by requirement for positive pressure ventilation in 29 patients (10 of whom had Acute Respiratory Distress Syndrome [ARDS]) and neurological symptoms in 24 patients. An important finding was the presence of diastolic dysfunction in 3 children. Six deaths of refractory shock included 4 who had ARDS and DIC and 2 who had shock with DIC 3 patients had abdominal compartment syndrome (ACS) has not been previously described in children with DSS and may lead to fluid refractory shock if not corrected. All patients had thrombocytopenia which was a defining feature of the syndrome, while 74 were also coagulopathic and 6 had severe fatal DIC. Hepatic dysfunction was more severe in children with prolonged shock, however, only a fifth of cases (5/24) with neurological manifestations were in shock. Other significant reasons for neurological presentation included cerebral edema, and encephalopathy secondary to hepatic dysfunction. 2 children had features of Acute Disseminated Encephalomyelitis (ADEM), previously only described in adults with dengue. CONCLUSION: It was found that complications such as DIC, diastolic dysfunction, abdominal compartment syndrome, ARDS and hepatic dysfunction were more frequent in severe established shock. However, most neurological events were unrelated to the perfusion status. Children referred late were harder to resuscitate. There were 9 PICU deaths (case fatality rate of 8.35%). Severe refractory shock, DIC, ARDS, hepatic failure and neurological manifestations singly or in combination were the commonest causes of death in the present study.
has issue date	2006-01-01(xsd:dateTime)
bibo:doi	10.1007/bf02859281
bibo:pmid	17090900
has license	no-cc
sha1sum (hex)	b16977a0967de62b7f4b23c797c9fb01a66b80be
schema:url	https://doi.org/10.1007/bf02859281
resource representing a document's title	Clinical features, complications and atypical manifestations of children with severe forms of dengue hemorrhagic fever in South India
has PubMed Central identifier	PMC7101810
has PubMed identifier	17090900
schema:publication	Indian J Pediatr
resource representing a document's body	covid:b16977a0967de62b7f4b23c797c9fb01a66b80be#body_text
is schema:about of	named entity 'presentation' named entity 'Manifestations' named entity 'Hemorrhagic' named entity 'PEDIATRIC INTENSIVE CARE UNIT' named entity 'presenting' named entity 'pediatric intensive care unit' named entity 'hemorrhagic fever' named entity 'Dengue' named entity 'PICU' named entity 'DHF' named entity 'Dengue Hemorrhagic Fever' named entity 'Hepatic dysfunction' named entity 'AST' named entity 'DIC' named entity 'PICU' named entity 'PICU' named entity 'DHF' named entity 'serology' named entity 'Intensive Care' named entity 'metabolic' named entity 'coagulopathy' named entity 'compartment syndrome' named entity 'exanthems' named entity 'refractory' named entity 'DIC' named entity 'lusitropic' named entity 'DHF' named entity 'cerebral edema' named entity 'metabolic' named entity 'ADEM' named entity 'MRI' named entity 'Hepatic dysfunction' named entity 'refractory' named entity 'left ventricular dysfunction' named entity 'ARDS' named entity 'systolic' named entity 'DSS' named entity 'CFR' named entity 'CSF' named entity 'diuretic' named entity 'Guillain Barre syndrome' named entity 'cardiac arrest' named entity 'DIC' named entity 'packed red blood cells' named entity 'anuria' named entity 'DHF' named entity 'metabolic acidosis' named entity 'dengue' named entity 'PICU' named entity 'DHF' named entity 'viral replication' named entity 'ADEM' named entity 'mucus' named entity 'DHF' named entity 'DIC' named entity 'CFR' named entity 'DHF' named entity 'PICU' named entity 'dengue fever' named entity 'E-mail' named entity 'case fatality rate' named entity 'antibody' named entity 'platelet counts' named entity 'DHF' named entity 'anasarca' named entity 'abdominal compartment syndrome' named entity 'neurologic' named entity 'abdominal compartment syndrome' named entity 'dengue' named entity 'seizures' named entity 'hemorrhage' named entity 'SVT' named entity 'Fulminant hepatic failure' named entity 'DHF' named entity 'partial thromboplastin time' named entity 'hyponatremia' named entity 'Chennai' named entity 'DHF' named entity 'Pediatric' named entity 'positive pressure ventilation'

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