About: Infectivity, susceptibility, and risk factors associated with SARS-CoV-2 transmission under intensive contact tracing in Hunan, China

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About: Infectivity, susceptibility, and risk factors associated with SARS-CoV-2 transmission under intensive contact tracing in Hunan, China Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Infectivity, susceptibility, and risk factors associated with SARS-CoV-2 transmission under intensive contact tracing in Hunan, China
Creator	Li, Jing Wang, Wei Wang, Yan Viboud, Cécile Yu, Hongjie Wang, Kai Yang, Hao Vespignani, Alessandro Li, J Wang, Y Ajelli, Marco Deng, Zhihong Chen, X Liu, Z Li, Mei Liang, Lu Chen, Xinhua Chen, Z Gao, L Li, M Litvinova, Maria Shi, H Sun, Kaiyuan Vespignani, A Wang, ( Wang, K Yang, H Yu, H Zheng, W Zheng, Wen Zhou, Y Yan, Han Luo, K Ren, L Chen, Xinghui Hu, S Sun, Q Chen, Zhiyuan Deng, Z Guo, J Zhou, Yonghong Luo, Kaiwei Yan, H Shi, Huilin Liu, Ziyan Ren, Lingshuang Sun, Qianlai Gao, Lidong Guo, Jinxin Hu, Shixiong Litvinova, ( Zeng, G Zeng, Ge
Source	MedRxiv; Medline
abstract	Abstract Importance Several parameters driving the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remain unclear, including age-specific differences in infectivity and susceptibility, and the contribution of inapparent infections to transmission. Robust estimates of key time-to-event distributions remain scarce as well. Objective Illustrate SARS-CoV-2 transmission patterns and risk factors, and estimate key time-to-event distributions. Design, Setting, and Participants Individual-based data on 1,178 SARS-CoV-2 infected individuals and their 15,648 contacts identified by contact tracing monitoring over the period from January 13-April 02, 2020 were extracted from the notifiable infectious diseases reporting system in Hunan Province, China. Demographic characteristics, severity classification, exposure and travel history, and key clinical timelines were retrieved. Exposures Confirmed SARS-CoV-2 infection by positive polymerase chain reaction test result of respiratory samples, and exposure to SARS-CoV-2 infected individuals via household, relative, social, and other types of contacts. Main Outcomes and Measures The relative contribution of pre-symptomatic and asymptomatic transmission, key time-to-event parameters, and the effect of biological, demographic, and behavioral factors on SARS-CoV-2 infectivity and susceptibility were quantified. Results Among SARS-CoV-2 infected individuals, the estimated mean serial interval was 5.5 days (95%CI -5.0, 19.9) and the mean generation time was 5.5 days (95%CI 1.7, 11.6). Infectiousness was estimated to peak 1.8 days before symptom onset, with 95% of transmission events occurring between -7.6 days and 7.3 days from the date of symptom onset. The proportion of pre-symptomatic transmission was estimated at 62.5%, while a lower bound for the proportion of asymptomatic transmission was 3.5%. Infectiousness of SARS-CoV-2 was not significantly different between working-age adults (15-59 years old) and other age groups (0-14 years old: p-value=0.16; 60 years and over: p-value=0.33), whilst susceptibility to SARS-CoV-2 infection was estimated to increase with age (p-value=0.03). In addition, transmission risk was higher for household contacts (p-value<0.001), but decreased in later generations of a cluster (second generation: OR=0.13, p-value<0.001; generations 3-4: OR=0.05, p-value<0.001, relative to generation 1) and for those exposed to infectors with a larger number of contacts (p-value=0.04). Conclusions and Relevance These findings support the contribution of children to transmission and the importance of pre-symptomatic transmission, in turn highlighting the importance of large-scale testing, contact tracing activities, and the use of personnel protective equipment during the COVID-19 pandemic.
has issue date	2020-07-24(xsd:dateTime)
bibo:doi	10.1101/2020.07.23.20160317
bibo:pmid	32793929
has license	medrxiv
sha1sum (hex)	b16a6e14859871a9e8004bcba871b0cd0f7e2e11
schema:url	https://doi.org/10.1101/2020.07.23.20160317
resource representing a document's title	Infectivity, susceptibility, and risk factors associated with SARS-CoV-2 transmission under intensive contact tracing in Hunan, China
has PubMed identifier	32793929
schema:publication	medRxiv : the preprint server for health sciences
resource representing a document's body	covid:b16a6e14859871a9e8004bcba871b0cd0f7e2e11#body_text
is schema:about of	named entity 'SARS-CoV-2' named entity '11.6' named entity 'risk factors' named entity 'Hunan' named entity 'generation time' named entity 'research funding' named entity 'Hunan Province' named entity 'symptom' named entity 'symptom' named entity 'contact tracing' named entity 'infection' named entity 'China' named entity '16.6' named entity 'AIC' named entity 'gamma distribution' named entity 'SARS-CoV-2' named entity 'pre-symptomatic' named entity 'SARS-CoV-2' named entity 'infection' named entity 'pre-symptomatic' named entity 'COVID-19' named entity 'gamma distribution' named entity '5.5' named entity 'lognormal' named entity 'COVID' named entity 'COVID' named entity '95% CI' named entity 'preprint' named entity 'preprint' named entity 'asymptomatic'

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