About: Sequence evidence for RNA recombination in field isolates of avian coronavirus infectious bronchitis virus

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Sequence evidence for RNA recombination in field isolates of avian coronavirus infectious bronchitis virus
Creator	Niesters, H Van Der Zeijst, B Jager, E Kusters, J
Source	Elsevier; Medline; PMC
abstract	Abstract Under laboratory conditions coronaviruses were shown to have a high frequency of recombination. In The Netherlands, vaccination against infectious bronchitis virus (IBV) is performed with vaccines that contain several life-attenuated virus strains. These highly effective vaccines may create ideal conditions for recombination, and could therefore be dangerous in the long term. This paper addresses the question of the frequency of recombination of avian coronavirus IBV in the field. A method was sought to detect and quantify recombination from sequence data. Nucleotide sequences of eight IBV isolates in a region of the genome suspected to contain recombination, were aligned and compared. Phylogenetic trees were constructed for different sections of this region. Differences in topology between these trees were observed, suggesting that in three out of eight strains in vivo RNA recombinant had occurred.
has issue date	1990-12-31(xsd:dateTime)
bibo:doi	10.1016/0264-410x(90)90018-h
bibo:pmid	1708184
has license	els-covid
sha1sum (hex)	b17a0f95bde622c07bd95ff3a9b983375e66ef8f
schema:url	https://doi.org/10.1016/0264-410x%2890%2990018-h
resource representing a document's title	Sequence evidence for RNA recombination in field isolates of avian coronavirus infectious bronchitis virus
has PubMed Central identifier	PMC7131616
has PubMed identifier	1708184
schema:publication	Vaccine
resource representing a document's body	covid:b17a0f95bde622c07bd95ff3a9b983375e66ef8f#body_text
is schema:about of	named entity 'INFECTIOUS BRONCHITIS VIRUS' named entity 'AVIAN CORONAVIRUS' named entity 'FIELD' named entity 'RNA' named entity 'OCCURRED' named entity 'SEQUENCE' named entity 'EVIDENCE FOR' named entity 'RECOMBINANT' named entity 'ISOLATES' named entity 'RNA RECOMBINATION' named entity 'RNA' named entity 'homologous genes' named entity 'vaccination' named entity 'reproductive organs' named entity 'amino acid replacement' named entity 'gene' named entity 'Phylogenetic trees' named entity 'Arg' named entity 'viruses' named entity 'Dutch' named entity 'Coronaviridae' named entity 'cDNA clones' named entity 'EMBL' named entity 'nucleotide sequences' named entity 'codon' named entity 'D207' named entity 'gene' named entity 'IBV' named entity 'recombination' named entity 'non-homologous recombination' named entity 'viruses' named entity 'point mutations' named entity 'recombination' named entity 'serotypes' named entity 'Dutch' named entity 'live attenuated' named entity 'Nucleotide Sequence' named entity 'Vaccine' named entity 'respiratory tract' named entity 'protein' named entity 'recombinants' named entity 'poultry industry' named entity 'mouse brain' named entity 'recombinant' named entity 'amino acid sequences' named entity 'gene' named entity 'C-terminal' named entity 'positive stranded RNA' named entity 'glycosylation sites' named entity 'Point mutations' named entity 'MHV' named entity 'Netherlands' named entity 'IBV' named entity 'codon' named entity 'RNA' named entity 'Arg' named entity 'virus' named entity 'gene' named entity 'infection' named entity 'laboratory conditions' named entity 'vaccines' named entity 'long term' named entity 'peplomer' named entity 'D207' named entity 'virion' named entity '3' end' named entity 'recombinant' named entity 'frequency of recombination' named entity 'glycoprotein' named entity 'recombination' named entity 'A59' named entity 'D207' named entity 'codon' named entity 'gene sequences' named entity 'recombination' named entity 'codon' named entity 'IBV' named entity 'antigenic'

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