About: Early predictors of clinical outcomes of COVID-19 outbreak in Milan, Italy

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Early predictors of clinical outcomes of COVID-19 outbreak in Milan, Italy
Creator	Milan, Italy Maria, Anna Adriano, Lazzarin Alberto, Ambrosio Alberto, Zangrillo Andrea, Poli Annalisa, Ruggeri Antonella, Castagna Antonella, Rovere-Querini Carlo, Martinenghi Carlo, Signorelli Caterina, Conte Cobelli, De Cobelli, Francesco Cristina, Tresoldi Efgeny, Fominskiy Eleonora, Bossi Emanuele, Bosi Fabio, Fabio, Castagna Fabio, Ciceri Giacomo, Monti Gianvito, Martino Giovanni, Landoni Hematology, Bone Laura, Galli Lorenzo, Dagna Luigi, Beretta Maria, Fazio Maria, Scandroglio Marzia, Spessot Massimo, Clementi Massimo, Locatelli Michele, Carlucci Milan, Ciceri Moreno, Tresoldi Paolo, Scarpellini Patrizia, Rovere-Querini Patrizia, De Rebecca, De Rebecca, Lorenzo Sergio, Colombo Stefano, Franchini Transplantation,
Source	Elsevier; Medline; PMC
abstract	BACKGROUND: National health-system hospitals of Lombardy faced a heavy burden of admissions for acute respiratory distress syndromes associated with coronavirus disease (COVID-19). Data on patients of European origin affected by COVID-19 are limited. METHODS: All consecutive patients aged ≥18 years, coming from North-East of Milan's province and admitted at San Raffaele Hospital with COVID-19, between February 25th and March 24th, were reported, all patients were followed for at least one month. Clinical and radiological features at admission and predictors of clinical outcomes were evaluated. RESULTS: Of the 500 patients admitted to the Emergency Unit, 410 patients were hospitalized and analyzed: median age was 65 (IQR 56–75) years, and the majority of patients were males (72.9%). Median (IQR) days from COVID-19 symptoms onset was 8 (5–11) days. At hospital admission, fever (≥ 37.5 °C) was present in 67.5% of patients. Median oxygen saturation (SpO2) was 93% (range 60–99), with median PaO(2)/FiO(2) ratio, 267 (IQR 184–314). Median Radiographic Assessment of Lung Edema (RALE) score was 9 (IQR 4–16). More than half of the patients (56.3%) had comorbidities, with hypertension, coronary heart disease, diabetes and chronic kidney failure being the most common. The probability of overall survival at day 28 was 66%. Multivariable analysis showed older age, coronary artery disease, cancer, low lymphocyte count and high RALE score as factors independently associated with an increased risk of mortality. CONCLUSION: In a large cohort of COVID-19 patients of European origin, main risk factors for mortality were older age, comorbidities, low lymphocyte count and high RALE.
has issue date	2020-06-12(xsd:dateTime)
bibo:doi	10.1016/j.clim.2020.108509
bibo:pmid	32535188
has license	no-cc
sha1sum (hex)	b19316cbc7c0133ce8367ed9b0ea98283289a531
schema:url	https://doi.org/10.1016/j.clim.2020.108509
resource representing a document's title	Early predictors of clinical outcomes of COVID-19 outbreak in Milan, Italy
has PubMed Central identifier	PMC7289745
has PubMed identifier	32535188
schema:publication	Clin Immunol
resource representing a document's body	covid:b19316cbc7c0133ce8367ed9b0ea98283289a531#body_text
is schema:about of	named entity 'Background' named entity 'HOSPITALS' named entity 'FACED' named entity 'ADMISSIONS' named entity 'Data' named entity 'Lombardy' named entity 'faced' named entity 'acute respiratory distress' named entity 'IL6' named entity 'IRB' named entity 'intensive care unit' named entity 'residual confounding' named entity 'lung edema' named entity 'Informed consent' named entity 'Older age' named entity 'COVID' named entity 'quantitative assessment' named entity 'eCRF' named entity 'China' named entity 'COVID' named entity 'coronary artery disease' named entity 'pleural effusion' named entity 'RT-PCR' named entity 'Europe' named entity 'China' named entity 'COVID' named entity 'lactate dehydrogenase' named entity 'monoclonal antibody' named entity 'lung' named entity 'older age' named entity 'northern Italy' named entity 'electrolytes' named entity 'hazard ratio' named entity 'vascular endothelial' named entity 'laboratory testing' named entity 'endothelium' named entity 'India' named entity 'hypertension'

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