About: First Dating of a Recombination Event in Mammalian Tick-Borne Flaviviruses

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About: First Dating of a Recombination Event in Mammalian Tick-Borne Flaviviruses Goto Sponge NotDistinct Permalink

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	First Dating of a Recombination Event in Mammalian Tick-Borne Flaviviruses
Creator	Bertrand, Y Johansson, M Elväng, A Melik, W Tö Pel, M
Source	PMC
abstract	The mammalian tick-borne flavivirus group (MTBFG) contains viruses associated with important human and animal diseases such as encephalitis and hemorrhagic fever. In contrast to mosquito-borne flaviviruses where recombination events are frequent, the evolutionary dynamic within the MTBFG was believed to be essentially clonal. This assumption was challenged with the recent report of several homologous recombinations within the Tick-borne encephalitis virus (TBEV). We performed a thorough analysis of publicly available genomes in this group and found no compelling evidence for the previously identified recombinations. However, our results show for the first time that demonstrable recombination (i.e., with large statistical support and strong phylogenetic evidences) has occurred in the MTBFG, more specifically within the Louping ill virus lineage. Putative parents, recombinant strains and breakpoints were further tested for statistical significance using phylogenetic methods. We investigated the time of divergence between the recombinant and parental strains in a Bayesian framework. The recombination was estimated to have occurred during a window of 282 to 76 years before the present. By unravelling the temporal setting of the event, we adduce hypotheses about the ecological conditions that could account for the observed recombination.
has issue date	2012-02-22(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0031981
bibo:pmid	22384119
has license	cc-by
sha1sum (hex)	b1d4318370f0bf32b2c6afded3ef07c1a37abe7a
schema:url	https://doi.org/10.1371/journal.pone.0031981
resource representing a document's title	First Dating of a Recombination Event in Mammalian Tick-Borne Flaviviruses
has PubMed Central identifier	PMC3285191
has PubMed identifier	22384119
schema:publication	PLoS One
resource representing a document's body	covid:b1d4318370f0bf32b2c6afded3ef07c1a37abe7a#body_text
is schema:about of	named entity 'EVENT' named entity 'setting' named entity 'hemorrhagic fever' named entity 'strong' named entity 'group' named entity 'GENOMES' named entity 'WHERE' named entity 'LINEAGE' named entity 'LOUPING ILL VIRUS' named entity 'STATISTICAL' named entity 'RESULTS' named entity 'PRESENT' named entity 'LARGE' named entity 'CONTRAST' named entity 'VIRUSES' named entity '282' named entity 'ASSOCIATED WITH' named entity 'ANIMAL DISEASES' named entity 'STATISTICAL SIGNIFICANCE' named entity 'RECOMBINANT' named entity 'STRONG' named entity 'OCCURRED' named entity 'ASSUMPTION' named entity 'MOSQUITO' named entity 'PARENTS' named entity 'AVAILABLE' named entity 'MAMMALIAN' named entity 'HEMORRHAGIC FEVER' named entity 'DEMONSTRABLE' named entity 'INVESTIGATED' named entity 'ANALYSIS' named entity 'TEMPORAL' named entity 'PERFORMED' named entity 'FREQUENT' named entity 'ESTIMATED' named entity 'BORNE' named entity 'CLONAL' named entity 'OUR' named entity 'TICK-BORNE ENCEPHALITIS VIRUS' named entity 'EVENTS' named entity 'GROUP' named entity 'RECENT' named entity 'TICK-BORNE FLAVIVIRUS' named entity 'FOUND' named entity 'PREVIOUSLY' named entity 'DIVERGENCE' named entity 'REPORT' named entity 'PARENTAL' named entity 'TICK' named entity 'MAMMALIAN' named entity 'FLAVIVIRUSES' named entity 'DATING' named entity 'RECOMBINATION' named entity 'YEARS' named entity 'DYNAMIC' named entity 'HOMOLOGOUS RECOMBINATIONS' named entity 'HAVE' named entity 'STRAINS' named entity 'USING' named entity 'ABOUT' named entity 'SETTING' named entity 'WINDOW' named entity 'OBSERVED' named entity 'IMPORTANT' named entity 'FLAVIVIRUSES' named entity 'CONDITIONS' named entity 'CONTAINS' named entity 'METHODS' named entity 'IDENTIFIED' named entity '28I' named entity 'ECOLOGICAL' named entity 'TESTED FOR' named entity 'EVIDENCE FOR' named entity 'BORNE' named entity 'SUPPORT' named entity 'EVENT' named entity 'ACCOUNT'

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