About: Anticancer potential of emodin

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Anticancer potential of emodin
Creator	Chung, Jing-Gung Hsu, Shu-Chun
source	Elsevier; Medline; PMC
abstract	Traditional Chinese Medicine (TCM) is widely used in clinical research due to its low toxicity, low number of side effects, and low cost. Many components of common fruits and vegetables play well-documented roles as chemopreventive or chemotherapeutic agents that suppress tumorigenesis. Anthraquinones are commonly extracted from the Polygonaceae family of plants, e.g., Rheum palmatum and Rheum officinale. Some of the major chemical components of anthraquinone and its derivatives, such as aloe-emodin, danthron, emodin, chrysophanol, physcion, and rhein, have demonstrated potential anticancer properties. This review evaluates the pharmacological effects of emodin, a major component of Aloe vera. In particular, emodin demonstrates anti-neoplastic, anti-inflammatory, anti-angiogenesis, and toxicological potential for use in pharmacology, both in vitro and in vivo. Emodin demonstrates cytotoxic effects (e.g., cell death) through the arrest of the cell cycle and the induction of apoptosis in cancer cells. The overall molecular mechanisms of emodin include cell cycle arrest, apoptosis, and the promotion of the expression of hypoxia-inducible factor 1α, glutathione S-transferase P, N-acetyltransferase, and glutathione phase I and II detoxification enzymes while inhibiting angiogenesis, invasion, migration, chemical-induced carcinogen-DNA adduct formation, HER2/neu, CKII kinase, and p34cdc2 kinase in human cancer cells. Hopefully, this summary will provide information regarding the actions of emodin in cancer cells and broaden the application potential of chemotherapy to additional cancer patients in the future.
has issue date	2012-05-11(xsd:dateTime)
bibo:doi	10.1016/j.biomed.2012.03.003
bibo:pmid	32289000
has license	no-cc
sha1sum (hex)	b205f1be8d3e522288ede5b4b0846062fa3a8596
schema:url	https://doi.org/10.1016/j.biomed.2012.03.003
resource representing a document's title	Anticancer potential of emodin
has PubMed Central identifier	PMC7104001
has PubMed identifier	32289000
schema:publication	Biomedicine (Taipei)
resource representing a document's body	covid:b205f1be8d3e522288ede5b4b0846062fa3a8596#body_text
is schema:about of	named entity 'Traditional Chinese Medicine (TCM)' named entity 'cell death' named entity 'Some' named entity 'aloe-emodin' named entity 'emodin' named entity 'COMPONENT' named entity 'COMMON' named entity 'MAJOR' named entity 'KEYWORDS' named entity 'CLINICAL RESEARCH' named entity 'RHEUM PALMATUM' named entity 'IN VIVO' named entity 'CHEMICAL' named entity 'COMPONENTS' named entity 'PROMOTION' named entity 'OVERALL' named entity 'CHRYSOPHANOL' named entity 'S T' named entity 'PARTICULAR' named entity 'ANTI-ANGIOGENESIS' named entity 'MECHANISMS' named entity 'HAVE' named entity 'GLUTATHIONE S-TRANSFERASE P' named entity 'POTENTIAL' named entity 'THE CELL' named entity 'INDUCTION OF APOPTOSIS' named entity '2C CELL' named entity 'COST' named entity 'ITS' named entity 'EMODIN' named entity 'TOXICOLOGICAL' named entity 'ANTI-INFLAMMATORY' named entity 'ANTICANCER' named entity 'DUE TO' named entity 'SUPPRESS' named entity 'RHEUM OFFICINALE' named entity 'PHYSCION' named entity 'ANTHRAQUINONE' named entity 'CYTOTOXIC' named entity 'CHEMOTHERAPEUTIC AGENTS' named entity 'NUMBER OF' named entity 'PHARMACOLOGY' named entity 'NEOPLASTIC' named entity 'EMODIN' named entity 'FAMILY' named entity 'CANCER CELLS' named entity 'REVIEW' named entity 'EXPRESSION' named entity 'DANTHRON' named entity 'PROPERTIES' named entity 'MOLECULAR' named entity 'ANTHRAQUINONES' named entity 'RHEIN' named entity 'DEMONSTRATED' named entity 'CELL CYCLE ARREST' named entity 'ANTICANCER' named entity 'ARREST' named entity 'HYPOXIA-INDUCIBLE FACTOR' named entity 'N-ACETYLTRANSFERASE' named entity 'A MAJOR' named entity 'USE' named entity 'APOPTOSIS' named entity 'PLANTS' named entity 'POLYGONACEAE' named entity 'EXTRACTED' named entity 'DOCUMENTED' named entity 'PLAY' named entity 'IN VITRO' named entity 'EFFECTS' named entity 'CELL DEATH' named entity 'ALOE-EMODIN' named entity 'LOW' named entity 'LOW TOXICITY' named entity 'ROLES' named entity 'USED' named entity 'CHEMOPREVENTIVE' named entity 'ANGIOGENESIS' named entity 'PHARMACOLOGICAL' named entity 'INCLUDE' named entity 'TRADITIONAL CHINESE MEDICINE'

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