About: Human Isolates of Lactic Acid Bacteria Differentially Affect Maturation and Cytokine Production by Human Dendritic Cells

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Human Isolates of Lactic Acid Bacteria Differentially Affect Maturation and Cytokine Production by Human Dendritic Cells
Creator	Thiel, Steffen Astrinidou-Vakaloudi, A Diamanti, I Georgakopoulou, E Hans, Reinholdt Hoffmann, Jürgen Jesper, Ralf Xatzidimitriou, D Xytsas, S
Source	PMC
abstract	The intestinal micro flora is indispensable in developing and maintaining homeostasis of the gut‐associated immune system. Evidence indicates that lactic acid bacteria (LAB), e.g. lactobacilli and bifidobacteria, have beneficial effects on the host. Established health effects include increased gut maturation, antagonisms towards pathogens and immune modulation. The objective of this study is to evaluate the immunomodulating properties of a range of LAB of human origin. As dendritic cells (DCs) play a pivotal role in the balance between tolerance and immunity to commensal microorganisms, in vitro‐generated immature DCs serve as a suitable model for studying the immunomodulating effects of lab. Human immature DCs were generated in vitro from monocytes and exposed to lethally UV‐irradiated LAB. The effect of various species of LAB on DCs in direct contact was evaluated. Furthermore, the maturation pattern of DCs separated from the bacteria by an epithelial cell layer (CaCo‐2 cells), which should mimic the intestinal environment, was studied. Cytokine secretion (IL‐12, IL‐10 and TNF‐α) and upregulation of maturation surface markers on DCs (CD83 and CD86) was measured. Different LAB induced diverse cytokine responses. Some strains were strong IL‐12 and TNF‐α inducers and others weak. All strains induced IL‐10. Different LAB also differentially modulated expression of CD83 and CD86 on DCs. Although some variation in the response to LAB of DCs generated from different blood donors was observed, general differences in the effect of the various LAB was revealed. Experiments with the DC CaCo‐2 coculture system are ongoing. Different species of LAB differentially affect DC maturation; this suggets that the gut flora plays a pivotal role in polarization of the immune response.
has issue date	2008-06-28(xsd:dateTime)
bibo:doi	10.1111/j.0300-9475.2004.01423aq.x
has license	no-cc
sha1sum (hex)	b210dbe6305d32e8e82cc55c87881e31627b24de
schema:url	https://doi.org/10.1111/j.0300-9475.2004.01423aq.x
resource representing a document's title	Human Isolates of Lactic Acid Bacteria Differentially Affect Maturation and Cytokine Production by Human Dendritic Cells
has PubMed Central identifier	PMC7169525
schema:publication	Scand J Immunol
resource representing a document's body	covid:b210dbe6305d32e8e82cc55c87881e31627b24de#body_text
is schema:about of	named entity 'antigen presentation' named entity 'HBsAg' named entity 'human lung' named entity 'lysis' named entity 'Kenya' named entity 'malignancies' named entity 'CD3' named entity 'TNF-a' named entity 'virus' named entity 'citrulline' named entity 'Bifidobacteria' named entity 'DCs' named entity 'serum' named entity 'exon' named entity 'IL-10' named entity 'signalling molecule' named entity 'apoptosis' named entity 'serum' named entity 'proteomes' named entity 'NK cells' named entity 'MBL' named entity 'protein' named entity 'Brussels' named entity 'complement' named entity 'ceramide' named entity 'antiviral' named entity 'CD8' named entity 'IFN-g' named entity 'S. aureus' named entity 'gastric juice' named entity 'weaning' named entity 'CD11b' named entity 'CBP' named entity 'IgG' named entity 'nonstructural protein' named entity 'hapten' named entity 'Heparin' named entity 'IgA' named entity 'fusion protein' named entity 'antibody' named entity 'haemodialysis' named entity 'CD8' named entity 'IL-10' named entity 'eosin' named entity 'polymorphisms' named entity 'protein' named entity 'immune status' named entity 'IgG' named entity 'Affymetrix' named entity 'mitochondrial enzyme' named entity 'gene' named entity 'protein microarrays' named entity 'TNF-a' named entity 'antitumour' named entity 'enzyme-linked immunosorbent assays' named entity 'pathogenesis' named entity 'Agios Pavlos' named entity 'macrophage' named entity 'lipoproteins' named entity 'neutrophile' named entity 'superfamily' named entity 'complement pathways' named entity 'Survivin' named entity 'risk factor' named entity 'flow cytometry' named entity 'biological properties' named entity 'cytokine' named entity 'ficolin' named entity 'LAB' named entity 'antigens' named entity 'piglet' named entity 'allele' named entity 'pathogen' named entity 'cytokine' named entity 'lectin pathway'

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